Cargando…

Control of Pim2 kinase stability and expression in transformed human haematopoietic cells

The oncogenic Pim2 kinase is overexpressed in several haematological malignancies, such as multiple myeloma and acute myeloid leukaemia (AML), and constitutes a strong therapeutic target candidate. Like other Pim kinases, Pim2 is constitutively active and is believed to be essentially regulated thro...

Descripción completa

Detalles Bibliográficos
Autores principales:	Adam, Kévin, Lambert, Mireille, Lestang, Elsa, Champenois, Gabriel, Dusanter-Fourt, Isabelle, Tamburini, Jérôme, Bouscary, Didier, Lacombe, Catherine, Zermati, Yael, Mayeux, Patrick
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Portland Press Ltd. 2015
Materias:	Original Papers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4672348/ https://www.ncbi.nlm.nih.gov/pubmed/26500282 http://dx.doi.org/10.1042/BSR20150217

Ejemplares similares

The epigenetic regulator RINF (CXXC5) maintains SMAD7 expression in human immature erythroid cells and sustains red blood cell expansion
por: Astori, Audrey, et al.
Publicado: (2020)

Pim kinases modulate resistance to FLT3 tyrosine kinase inhibitors in FLT3-ITD acute myeloid leukemia
por: Green, Alexa S., et al.
Publicado: (2015)

Finely-tuned regulation of AMP-activated protein kinase is crucial for human adult erythropoiesis
por: Ladli, Meriem, et al.
Publicado: (2019)

FOXP1 regulates oxidative stress, SIRT1 expression, and resistance to chemotherapies in acute myeloid leukemia cells
por: Levavasseur, Francoise, et al.
Publicado: (2023)

Caspase Activation Is Required for Terminal Erythroid Differentiation
por: Zermati, Yael, et al.
Publicado: (2001)

Rationale for Targeting Deregulated Metabolic Pathways as a Therapeutic Strategy in Acute Myeloid Leukemia
por: Chapuis, Nicolas, et al.
Publicado: (2019)

PIM Kinases in Multiple Myeloma
por: Wu, Jian, et al.
Publicado: (2021)

The role of PIM1/PIM2 kinases in tumors of the male reproductive system
por: Jiménez-García, Manuel Pedro, et al.
Publicado: (2016)

Integrated analyses of translatome and proteome identify the rules of translation selectivity in RPS14-deficient cells
por: Boussaid, Ismael, et al.
Publicado: (2020)

Antileukemic activity of the VPS34-IN1 inhibitor in acute myeloid leukemia
por: Meunier, Godelieve, et al.
Publicado: (2020)

Targeting the Pim kinases in multiple myeloma
por: Keane, N A, et al.
Publicado: (2015)

A review on PIM kinases in tumors
por: Arrouchi, Housna, et al.
Publicado: (2019)

PIM Kinase as an Executional Target in Cancer
por: Zhang, Xinning, et al.
Publicado: (2018)

Protein kinase PIM2: A simple PIM family kinase with complex functions in cancer metabolism and therapeutics
por: Wang, Yixin, et al.
Publicado: (2021)

The Role of PIM Kinases in Pediatric Solid Tumors
por: Julson, Janet Rae, et al.
Publicado: (2022)

Targeting PIM Kinases to Improve the Efficacy of Immunotherapy
por: Clements, Amber N., et al.
Publicado: (2022)

[Retracted] Expression and function of PIM kinases in osteosarcoma
por: Mou, Shuai, et al.
Publicado: (2023)

Pim Kinases: Important Regulators of Cardiovascular Disease
por: Nock, Sophie, et al.
Publicado: (2023)

Inflammation and stem markers association to PIM1/PIM2 kinase-induced tumors in breast and uterus
por: Jiménez-García, Manuel-Pedro, et al.
Publicado: (2017)

Dibenzofuran Derivatives Inspired from Cercosporamide as Dual Inhibitors of Pim and CLK1 Kinases
por: Dao, Viet Hung, et al.
Publicado: (2021)

Pim-selective inhibitor DHPCC-9 reveals Pim kinases as potent stimulators of cancer cell migration and invasion
por: Santio, Niina M, et al.
Publicado: (2010)

PIM kinases as therapeutic targets against advanced melanoma
por: Shannan, Batool, et al.
Publicado: (2016)

PIM kinases mediate resistance to cisplatin chemotherapy in hepatoblastoma
por: Marayati, Raoud, et al.
Publicado: (2021)

Expression and ERG regulation of PIM kinases in prostate cancer
por: Eerola, Sini K., et al.
Publicado: (2021)

An overview of pim kinase as a target in multiple myeloma
por: Liu, Zhaoyun, et al.
Publicado: (2023)

S163: POLYSOME INTERACTOME IN RPS14-DEFICIENT CELLS REVEALS THE INVOLVEMENT OF THE MRNA DECAY MACHINERY IN TRANSLATION SELECTIVITY.
por: Tuerdi, Zubaidan, et al.
Publicado: (2023)

Comprehensive Proteomic Analysis of Human Erythropoiesis
por: Gautier, Emilie-Fleur, et al.
Publicado: (2016)

FLT3 inhibitors: clinical potential in acute myeloid leukemia
por: Hospital, Marie-Anne, et al.
Publicado: (2017)

The Pim kinases control rapamycin-resistant T cell survival and activation
por: Fox, Casey J., et al.
Publicado: (2005)

Crystal Structure of the PIM2 Kinase in Complex with an Organoruthenium Inhibitor
por: Bullock, Alex N., et al.
Publicado: (2009)

Abnormal hematopoietic phenotypes in Pim kinase triple knockout mice
por: An, Ningfei, et al.
Publicado: (2013)

Pim1 kinase regulates c-Kit gene translation
por: An, Ningfei, et al.
Publicado: (2016)

Targeting PIM kinase as a therapeutic strategy in human hepatoblastoma
por: Stafman, Laura L., et al.
Publicado: (2018)

Targeting PIM kinases to oppose hypoxia-mediated therapeutic resistance
por: Chauhan, Shailender S., et al.
Publicado: (2018)

Stabilization of PIM Kinases in Hypoxia Is Mediated by the Deubiquitinase USP28
por: Toth, Rachel K., et al.
Publicado: (2022)

Pim-2 Kinase Regulates Energy Metabolism in Multiple Myeloma
por: Liu, Zhaoyun, et al.
Publicado: (2022)

Targeting Pim kinases in hematological cancers: molecular and clinical review
por: Bellon, Marcia, et al.
Publicado: (2023)

KSHV Reactivation from Latency Requires Pim-1 and Pim-3 Kinases to Inactivate the Latency-Associated Nuclear Antigen LANA
por: Cheng, Fang, et al.
Publicado: (2009)

The direct Myc target Pim3 cooperates with other Pim kinases in supporting viability of Myc-induced B-cell lymphomas
por: Forshell, Linus Plym, et al.
Publicado: (2011)

Loss of PIM2 enhances the anti-proliferative effect of the pan-PIM kinase inhibitor AZD1208 in non-Hodgkin lymphomas
por: Kreuz, S., et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_18s1l46ine8hdembbpt2ikcdel