Cell cycle and p53 gate the direct conversion of human fibroblasts to dopaminergic neurons

The direct conversion of fibroblasts to induced dopaminergic (iDA) neurons and other cell types demonstrates the plasticity of cell fate. The low efficiency of these relatively fast conversions suggests that kinetic barriers exist to safeguard cell-type identity. Here we show that suppression of p53...

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Detalles Bibliográficos
Autores principales: Jiang, Houbo, Xu, Zhimin, Zhong, Ping, Ren, Yong, Liang, Gaoyang, Schilling, Haley A., Hu, Zihua, Zhang, Yi, Wang, Xiaomin, Chen, Shengdi, Yan, Zhen, Feng, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4672381/
https://www.ncbi.nlm.nih.gov/pubmed/26639555
http://dx.doi.org/10.1038/ncomms10100

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