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Burkholderia cepacia complex: clinical course in cystic fibrosis patients
BACKGROUND: Pulmonary deterioration after B.cepacia complex (BCC) colonization has a heterogeneous pattern. The aim was to investigate the clinical outcome of BCC colonization in CF patients chronically colonized with P. aeruginosa. METHODS: CF patients chronically colonized with P. aeruginosa were...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4672471/ https://www.ncbi.nlm.nih.gov/pubmed/26642758 http://dx.doi.org/10.1186/s12890-015-0148-2 |
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author | Folescu, Tania Wrobel da Costa, Claudia Henrique Cohen, Renata Wrobel Folescu Neto, Orlando Carlos da Conceição Albano, Rodolpho Mattos Marques, Elizabeth Andrade |
author_facet | Folescu, Tania Wrobel da Costa, Claudia Henrique Cohen, Renata Wrobel Folescu Neto, Orlando Carlos da Conceição Albano, Rodolpho Mattos Marques, Elizabeth Andrade |
author_sort | Folescu, Tania Wrobel |
collection | PubMed |
description | BACKGROUND: Pulmonary deterioration after B.cepacia complex (BCC) colonization has a heterogeneous pattern. The aim was to investigate the clinical outcome of BCC colonization in CF patients chronically colonized with P. aeruginosa. METHODS: CF patients chronically colonized with P. aeruginosa were divided into three groups: intermittent (I), chronic (II) and no colonization (III) with BCC. Body mass index (BMI) percentile and spirometric parameters were analyzed at three different times in each group. RESULTS: Fifty-six patients chronically colonized with P. aeruginosa were included. Of these, 27 also had evidence of BCC colonization (13 intermittent and 14 chronic). BMI percentile was significantly lower among patients chronically colonized by both P. aeruginosa and BCC. Mean values of FEV(1) and FVC % were also significantly lower in these patients, both at the time of chronic BCC colonization and 24 months forward. CONCLUSIONS: Chronic BCC colonization is associated with significant loss of lung function. Lower BMI might be a risk factor for chronic BCC colonization, preceding these events. |
format | Online Article Text |
id | pubmed-4672471 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-46724712015-12-09 Burkholderia cepacia complex: clinical course in cystic fibrosis patients Folescu, Tania Wrobel da Costa, Claudia Henrique Cohen, Renata Wrobel Folescu Neto, Orlando Carlos da Conceição Albano, Rodolpho Mattos Marques, Elizabeth Andrade BMC Pulm Med Research Article BACKGROUND: Pulmonary deterioration after B.cepacia complex (BCC) colonization has a heterogeneous pattern. The aim was to investigate the clinical outcome of BCC colonization in CF patients chronically colonized with P. aeruginosa. METHODS: CF patients chronically colonized with P. aeruginosa were divided into three groups: intermittent (I), chronic (II) and no colonization (III) with BCC. Body mass index (BMI) percentile and spirometric parameters were analyzed at three different times in each group. RESULTS: Fifty-six patients chronically colonized with P. aeruginosa were included. Of these, 27 also had evidence of BCC colonization (13 intermittent and 14 chronic). BMI percentile was significantly lower among patients chronically colonized by both P. aeruginosa and BCC. Mean values of FEV(1) and FVC % were also significantly lower in these patients, both at the time of chronic BCC colonization and 24 months forward. CONCLUSIONS: Chronic BCC colonization is associated with significant loss of lung function. Lower BMI might be a risk factor for chronic BCC colonization, preceding these events. BioMed Central 2015-12-08 /pmc/articles/PMC4672471/ /pubmed/26642758 http://dx.doi.org/10.1186/s12890-015-0148-2 Text en © Folescu et al. 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Folescu, Tania Wrobel da Costa, Claudia Henrique Cohen, Renata Wrobel Folescu Neto, Orlando Carlos da Conceição Albano, Rodolpho Mattos Marques, Elizabeth Andrade Burkholderia cepacia complex: clinical course in cystic fibrosis patients |
title | Burkholderia cepacia complex: clinical course in cystic fibrosis patients |
title_full | Burkholderia cepacia complex: clinical course in cystic fibrosis patients |
title_fullStr | Burkholderia cepacia complex: clinical course in cystic fibrosis patients |
title_full_unstemmed | Burkholderia cepacia complex: clinical course in cystic fibrosis patients |
title_short | Burkholderia cepacia complex: clinical course in cystic fibrosis patients |
title_sort | burkholderia cepacia complex: clinical course in cystic fibrosis patients |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4672471/ https://www.ncbi.nlm.nih.gov/pubmed/26642758 http://dx.doi.org/10.1186/s12890-015-0148-2 |
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