A new design of a lentiviral shRNA vector with inducible co-expression of ARGONAUTE 2 for enhancing gene silencing efficiency

BACKGROUND: RNA interference (RNAi) is a robust tool for inhibiting specific gene expression, but it is limited by the uncertain efficiency of siRNA or shRNA constructs. It has been shown that the overexpression of ARGONAUTE 2 (AGO2) protein increases silencing efficiency. However, the key elements...

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Detalles Bibliográficos
Autores principales: He, Jiening, Huang, Lian, Qiu, Huiling, Li, Jiexuan, Luo, Lan, Li, Yanjiao, Tian, Shengli, Kang, Kang, Luo, Jun, Liu, Lin, Gou, Deming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Methodology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4672530/
https://www.ncbi.nlm.nih.gov/pubmed/26649169
http://dx.doi.org/10.1186/s13578-015-0058-2

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