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The interaction of lubricin/proteoglycan 4 (PRG4) with toll-like receptors 2 and 4: an anti-inflammatory role of PRG4 in synovial fluid

BACKGROUND: Lubricin/proteoglycan-4 (PRG4) is a mucinous glycoprotein secreted by synovial fibroblasts and superficial zone chondrocytes. PRG4 has a homeostatic multifaceted role in the joint. PRG4 intra-articular treatment retards progression of cartilage degeneration in pre-clinical posttraumatic...

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Detalles Bibliográficos
Autores principales:	Alquraini, Ali, Garguilo, Steven, D’Souza, Gerard, Zhang, Ling X., Schmidt, Tannin A., Jay, Gregory D., Elsaid, Khaled A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4672561/ https://www.ncbi.nlm.nih.gov/pubmed/26643105 http://dx.doi.org/10.1186/s13075-015-0877-x

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