Cranial and spinal leptomeningeal dissemination in esthesioneuroblastoma: Two reports of distant central nervous system metastasis and rationale for treatment

BACKGROUND: Esthesioneuroblastoma is a locally aggressive cancer of the nasal cavity. While systemic metastasis can occur in 10-30% of patients, there are only six reported cases of distal metastasis from leptomeningeal dissemination. CASE DESCRIPTION: The authors report two cases of esthesioneurobl...

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Autores principales: Sivakumar, Walavan, Oh, Nathan, Cutler, Aaron, Colman, Howard, Couldwell, William T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2015
Materias:
Surgical Neurology International: Unique Case Observations
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4672577/
https://www.ncbi.nlm.nih.gov/pubmed/26682087
http://dx.doi.org/10.4103/2152-7806.170464
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author Sivakumar, Walavan
Oh, Nathan
Cutler, Aaron
Colman, Howard
Couldwell, William T.
author_facet Sivakumar, Walavan
Oh, Nathan
Cutler, Aaron
Colman, Howard
Couldwell, William T.
author_sort Sivakumar, Walavan
collection PubMed
description BACKGROUND: Esthesioneuroblastoma is a locally aggressive cancer of the nasal cavity. While systemic metastasis can occur in 10-30% of patients, there are only six reported cases of distal metastasis from leptomeningeal dissemination. CASE DESCRIPTION: The authors report two cases of esthesioneuroblastoma treated previously with multimodal therapy in which distal metastatic recurrence was found and describe their treatment protocol, which has resulted in long-term success. CONCLUSION: Understanding the drivers of leptomeningeal dissemination in more prevalent primary neuroectodermal tumors may hold the key to developing successful treatment algorithms for this disease.
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spelling pubmed-46725772015-12-17 Cranial and spinal leptomeningeal dissemination in esthesioneuroblastoma: Two reports of distant central nervous system metastasis and rationale for treatment Sivakumar, Walavan Oh, Nathan Cutler, Aaron Colman, Howard Couldwell, William T. Surg Neurol Int Surgical Neurology International: Unique Case Observations BACKGROUND: Esthesioneuroblastoma is a locally aggressive cancer of the nasal cavity. While systemic metastasis can occur in 10-30% of patients, there are only six reported cases of distal metastasis from leptomeningeal dissemination. CASE DESCRIPTION: The authors report two cases of esthesioneuroblastoma treated previously with multimodal therapy in which distal metastatic recurrence was found and describe their treatment protocol, which has resulted in long-term success. CONCLUSION: Understanding the drivers of leptomeningeal dissemination in more prevalent primary neuroectodermal tumors may hold the key to developing successful treatment algorithms for this disease. Medknow Publications & Media Pvt Ltd 2015-11-25 /pmc/articles/PMC4672577/ /pubmed/26682087 http://dx.doi.org/10.4103/2152-7806.170464 Text en Copyright: © 2015 Surgical Neurology International http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Surgical Neurology International: Unique Case Observations
Sivakumar, Walavan
Oh, Nathan
Cutler, Aaron
Colman, Howard
Couldwell, William T.
Cranial and spinal leptomeningeal dissemination in esthesioneuroblastoma: Two reports of distant central nervous system metastasis and rationale for treatment
title Cranial and spinal leptomeningeal dissemination in esthesioneuroblastoma: Two reports of distant central nervous system metastasis and rationale for treatment
title_full Cranial and spinal leptomeningeal dissemination in esthesioneuroblastoma: Two reports of distant central nervous system metastasis and rationale for treatment
title_fullStr Cranial and spinal leptomeningeal dissemination in esthesioneuroblastoma: Two reports of distant central nervous system metastasis and rationale for treatment
title_full_unstemmed Cranial and spinal leptomeningeal dissemination in esthesioneuroblastoma: Two reports of distant central nervous system metastasis and rationale for treatment
title_short Cranial and spinal leptomeningeal dissemination in esthesioneuroblastoma: Two reports of distant central nervous system metastasis and rationale for treatment
title_sort cranial and spinal leptomeningeal dissemination in esthesioneuroblastoma: two reports of distant central nervous system metastasis and rationale for treatment
topic Surgical Neurology International: Unique Case Observations
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4672577/
https://www.ncbi.nlm.nih.gov/pubmed/26682087
http://dx.doi.org/10.4103/2152-7806.170464
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