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Giant cell tumors of the clivus: Case report and literature review

BACKGROUND: Clival giant cell tumors (GCTs) are extremely rare with only eight cases reported to date, and malignant transformation is quite rare. Herein, we report a case of an uncontrolled clival GCT, which was transformed malignant, and review the literature. CASE DESCRIPTION: A 25-year-old man e...

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Detalles Bibliográficos
Autores principales: Shibao, Shunsuke, Toda, Masahiro, Yoshida, Kazunari
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4672581/
https://www.ncbi.nlm.nih.gov/pubmed/26682086
http://dx.doi.org/10.4103/2152-7806.170459
Descripción
Sumario:BACKGROUND: Clival giant cell tumors (GCTs) are extremely rare with only eight cases reported to date, and malignant transformation is quite rare. Herein, we report a case of an uncontrolled clival GCT, which was transformed malignant, and review the literature. CASE DESCRIPTION: A 25-year-old man experienced double vision for 1 month. Computed tomography and magnetic resonance imaging revealed a clival tumor. The endonasal endoscopic transsphenoidal approach (EEA) was used, and partial resection was performed because of massive bleeding. Histological examination showed a GCT. After radiation therapy, the tumor recurred; the EEA and the anterior transpetrosal approaches were used to perform second and third operations, respectively. The MIB-1 index increased from 4.2% to 26.3%. CONCLUSIONS: GCTs are difficult to treat because of their location, vascularity, and the potential for malignant transformation.