Lifespan Extension Induced by Caffeine in Caenorhabditis elegans is Partially Dependent on Adenosine Signaling

Caffeine is a widely used psychoactive substance. Studies have shown that caffeine may play a protective role in aging-associated disorders. However, the mechanisms by which caffeine modulates aging are not yet clear. In this study, we have shown that caffeine increases Caenorhabditis elegans lifesp...

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Autores principales: Bridi, Jessika Cristina, Barros, Alexandre Guimarães de Almeida, Sampaio, Letícia Reis, Ferreira, Júlia Castro Damásio, Antunes Soares, Felix Alexandre, Romano-Silva, Marco Aurélio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4672644/
https://www.ncbi.nlm.nih.gov/pubmed/26696878
http://dx.doi.org/10.3389/fnagi.2015.00220
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author Bridi, Jessika Cristina
Barros, Alexandre Guimarães de Almeida
Sampaio, Letícia Reis
Ferreira, Júlia Castro Damásio
Antunes Soares, Felix Alexandre
Romano-Silva, Marco Aurélio
author_facet Bridi, Jessika Cristina
Barros, Alexandre Guimarães de Almeida
Sampaio, Letícia Reis
Ferreira, Júlia Castro Damásio
Antunes Soares, Felix Alexandre
Romano-Silva, Marco Aurélio
author_sort Bridi, Jessika Cristina
collection PubMed
description Caffeine is a widely used psychoactive substance. Studies have shown that caffeine may play a protective role in aging-associated disorders. However, the mechanisms by which caffeine modulates aging are not yet clear. In this study, we have shown that caffeine increases Caenorhabditis elegans lifespan, delays its larval development, reduces reproduction and body length. These phenotypes were partly reversed by worm’s exposure to adenosine, which suggest a putative common target. Moreover, they were dependent on a functional insulin/IGF-1-like pathway. Our results may shed light on new genetic determinants of aging.
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spelling pubmed-46726442015-12-22 Lifespan Extension Induced by Caffeine in Caenorhabditis elegans is Partially Dependent on Adenosine Signaling Bridi, Jessika Cristina Barros, Alexandre Guimarães de Almeida Sampaio, Letícia Reis Ferreira, Júlia Castro Damásio Antunes Soares, Felix Alexandre Romano-Silva, Marco Aurélio Front Aging Neurosci Neuroscience Caffeine is a widely used psychoactive substance. Studies have shown that caffeine may play a protective role in aging-associated disorders. However, the mechanisms by which caffeine modulates aging are not yet clear. In this study, we have shown that caffeine increases Caenorhabditis elegans lifespan, delays its larval development, reduces reproduction and body length. These phenotypes were partly reversed by worm’s exposure to adenosine, which suggest a putative common target. Moreover, they were dependent on a functional insulin/IGF-1-like pathway. Our results may shed light on new genetic determinants of aging. Frontiers Media S.A. 2015-12-08 /pmc/articles/PMC4672644/ /pubmed/26696878 http://dx.doi.org/10.3389/fnagi.2015.00220 Text en Copyright © 2015 Bridi, Barros, Sampaio, Ferreira, Antunes Soares and Romano-Silva. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Bridi, Jessika Cristina
Barros, Alexandre Guimarães de Almeida
Sampaio, Letícia Reis
Ferreira, Júlia Castro Damásio
Antunes Soares, Felix Alexandre
Romano-Silva, Marco Aurélio
Lifespan Extension Induced by Caffeine in Caenorhabditis elegans is Partially Dependent on Adenosine Signaling
title Lifespan Extension Induced by Caffeine in Caenorhabditis elegans is Partially Dependent on Adenosine Signaling
title_full Lifespan Extension Induced by Caffeine in Caenorhabditis elegans is Partially Dependent on Adenosine Signaling
title_fullStr Lifespan Extension Induced by Caffeine in Caenorhabditis elegans is Partially Dependent on Adenosine Signaling
title_full_unstemmed Lifespan Extension Induced by Caffeine in Caenorhabditis elegans is Partially Dependent on Adenosine Signaling
title_short Lifespan Extension Induced by Caffeine in Caenorhabditis elegans is Partially Dependent on Adenosine Signaling
title_sort lifespan extension induced by caffeine in caenorhabditis elegans is partially dependent on adenosine signaling
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4672644/
https://www.ncbi.nlm.nih.gov/pubmed/26696878
http://dx.doi.org/10.3389/fnagi.2015.00220
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