Rational, yet simple, design and synthesis of an antifreeze-protein inspired polymer for cellular cryopreservation

Antifreeze (glyco) proteins AF(G)Ps are potent ice recrystallization inhibitors, which is a desirable property to enhance cryopreservation of donor tissue/cells. Here we present the rational synthesis of a new, biomimetic, ice-recrystallization inhibiting polymer derived from a cheap commodity polym...

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Detalles Bibliográficos
Autores principales: Mitchell, Daniel E., Cameron, Neil R., Gibson, Matthew I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2015
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4672748/
https://www.ncbi.nlm.nih.gov/pubmed/26176027
http://dx.doi.org/10.1039/c5cc04647e
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author Mitchell, Daniel E.
Cameron, Neil R.
Gibson, Matthew I.
author_facet Mitchell, Daniel E.
Cameron, Neil R.
Gibson, Matthew I.
author_sort Mitchell, Daniel E.
collection PubMed
description Antifreeze (glyco) proteins AF(G)Ps are potent ice recrystallization inhibitors, which is a desirable property to enhance cryopreservation of donor tissue/cells. Here we present the rational synthesis of a new, biomimetic, ice-recrystallization inhibiting polymer derived from a cheap commodity polymer, based on an ampholyte structure. The polymer is used to enhance the cryopreservation of red blood cells, demonstrating a macromolecular solution to tissue storage.
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spelling pubmed-46727482015-12-14 Rational, yet simple, design and synthesis of an antifreeze-protein inspired polymer for cellular cryopreservation Mitchell, Daniel E. Cameron, Neil R. Gibson, Matthew I. Chem Commun (Camb) Chemistry Antifreeze (glyco) proteins AF(G)Ps are potent ice recrystallization inhibitors, which is a desirable property to enhance cryopreservation of donor tissue/cells. Here we present the rational synthesis of a new, biomimetic, ice-recrystallization inhibiting polymer derived from a cheap commodity polymer, based on an ampholyte structure. The polymer is used to enhance the cryopreservation of red blood cells, demonstrating a macromolecular solution to tissue storage. Royal Society of Chemistry 2015-08-21 2015-07-15 /pmc/articles/PMC4672748/ /pubmed/26176027 http://dx.doi.org/10.1039/c5cc04647e Text en This journal is © The Royal Society of Chemistry 2015 http://creativecommons.org/licenses/by/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution 3.0 Unported License (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Chemistry
Mitchell, Daniel E.
Cameron, Neil R.
Gibson, Matthew I.
Rational, yet simple, design and synthesis of an antifreeze-protein inspired polymer for cellular cryopreservation
title Rational, yet simple, design and synthesis of an antifreeze-protein inspired polymer for cellular cryopreservation
title_full Rational, yet simple, design and synthesis of an antifreeze-protein inspired polymer for cellular cryopreservation
title_fullStr Rational, yet simple, design and synthesis of an antifreeze-protein inspired polymer for cellular cryopreservation
title_full_unstemmed Rational, yet simple, design and synthesis of an antifreeze-protein inspired polymer for cellular cryopreservation
title_short Rational, yet simple, design and synthesis of an antifreeze-protein inspired polymer for cellular cryopreservation
title_sort rational, yet simple, design and synthesis of an antifreeze-protein inspired polymer for cellular cryopreservation
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4672748/
https://www.ncbi.nlm.nih.gov/pubmed/26176027
http://dx.doi.org/10.1039/c5cc04647e
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