Characterization of a Novel Human-Specific STING Agonist that Elicits Antiviral Activity Against Emerging Alphaviruses

Pharmacologic stimulation of innate immune processes represents an attractive strategy to achieve multiple therapeutic outcomes including inhibition of virus replication, boosting antitumor immunity, and enhancing vaccine immunogenicity. In light of this we sought to identify small molecules capable...

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Detalles Bibliográficos
Autores principales: Sali, Tina M., Pryke, Kara M., Abraham, Jinu, Liu, Andrew, Archer, Iris, Broeckel, Rebecca, Staverosky, Julia A., Smith, Jessica L., Al-Shammari, Ahmed, Amsler, Lisi, Sheridan, Kayla, Nilsen, Aaron, Streblow, Daniel N., DeFilippis, Victor R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4672893/
https://www.ncbi.nlm.nih.gov/pubmed/26646986
http://dx.doi.org/10.1371/journal.ppat.1005324

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