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Cdk5 and Foxc2 – a new relationship in the lymphatic vasculature
Lymphatic vessel dysfunction is associated with various pathologic conditions, including immunologic disorders, lymphedema, as well as tumor dissemination. Yet, the knowledge about the regulation of lymphatic vessel development is still limited. Our study elucidates cyclin dependent kinase 5 (Cdk5)...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Impact Journals LLC
2015
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4673126/ https://www.ncbi.nlm.nih.gov/pubmed/26327394 |
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author | Liebl, Johanna |
author_facet | Liebl, Johanna |
author_sort | Liebl, Johanna |
collection | PubMed |
description | Lymphatic vessel dysfunction is associated with various pathologic conditions, including immunologic disorders, lymphedema, as well as tumor dissemination. Yet, the knowledge about the regulation of lymphatic vessel development is still limited. Our study elucidates cyclin dependent kinase 5 (Cdk5) as an essential player in the development of lymphatic vessels. Deletion of Cdk5 in the mouse endothelium results in severe lymphedema formation and embryonic lethality. On the mechanistic level, we show that Cdk5 phosphorylates the forkhead transcription factor Foxc2 which regulates Foxc2-dependent transcription. In summary, our study elucidates the Cdk5-Foxc2 interaction as a critical regulator of lymphatic vessel development. |
format | Online Article Text |
id | pubmed-4673126 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-46731262015-12-23 Cdk5 and Foxc2 – a new relationship in the lymphatic vasculature Liebl, Johanna Oncotarget Research Perspective Lymphatic vessel dysfunction is associated with various pathologic conditions, including immunologic disorders, lymphedema, as well as tumor dissemination. Yet, the knowledge about the regulation of lymphatic vessel development is still limited. Our study elucidates cyclin dependent kinase 5 (Cdk5) as an essential player in the development of lymphatic vessels. Deletion of Cdk5 in the mouse endothelium results in severe lymphedema formation and embryonic lethality. On the mechanistic level, we show that Cdk5 phosphorylates the forkhead transcription factor Foxc2 which regulates Foxc2-dependent transcription. In summary, our study elucidates the Cdk5-Foxc2 interaction as a critical regulator of lymphatic vessel development. Impact Journals LLC 2015-07-13 /pmc/articles/PMC4673126/ /pubmed/26327394 Text en Copyright: © 2015 Liebl http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Perspective Liebl, Johanna Cdk5 and Foxc2 – a new relationship in the lymphatic vasculature |
title | Cdk5 and Foxc2 – a new relationship in the lymphatic vasculature |
title_full | Cdk5 and Foxc2 – a new relationship in the lymphatic vasculature |
title_fullStr | Cdk5 and Foxc2 – a new relationship in the lymphatic vasculature |
title_full_unstemmed | Cdk5 and Foxc2 – a new relationship in the lymphatic vasculature |
title_short | Cdk5 and Foxc2 – a new relationship in the lymphatic vasculature |
title_sort | cdk5 and foxc2 – a new relationship in the lymphatic vasculature |
topic | Research Perspective |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4673126/ https://www.ncbi.nlm.nih.gov/pubmed/26327394 |
work_keys_str_mv | AT liebljohanna cdk5andfoxc2anewrelationshipinthelymphaticvasculature |