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Downregulation of c-SRC kinase CSK promotes castration resistant prostate cancer and pinpoints a novel disease subclass

SRC kinase is activated in castration resistant prostate cancer (CRPC), phosphorylates the androgen receptor (AR), and causes its ligand-independent activation as a transcription factor. However, activating SRC mutations are exceedingly rare in human tumors, and mechanisms of ectopic SRC activation...

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Detalles Bibliográficos
Autores principales:	Yang, Chih-Cheng, Fazli, Ladan, Loguercio, Salvatore, Zharkikh, Irina, Aza-Blanc, Pedro, Gleave, Martin E., Wolf, Dieter A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2015
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4673146/ https://www.ncbi.nlm.nih.gov/pubmed/26091350

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