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Discovery of benzo[e]pyridoindolones as kinase inhibitors that disrupt mitosis exit while erasing AMPK-Thr172 phosphorylation on the spindle
Aurora kinases play an essential role in mitotic progression and are attractive targets in cancer therapy. The first generation of benzo[e]pyridoindole exhibited powerful aurora kinase inhibition but their low solubility limited further development. Grafting a pyperidine-ethoxy group gives rise to a...
Autores principales: | Le, Ly-Thuy-Tram, Couvet, Morgane, Favier, Bertrand, Coll, Jean-Luc, Nguyen, Chi-Hung, Molla, Annie |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4673153/ https://www.ncbi.nlm.nih.gov/pubmed/26247630 |
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