Targeting TRAP1 as a downstream effector of BRAF cytoprotective pathway: A novel strategy for human BRAF-driven colorectal carcinoma

The HSP90 chaperone TRAP1 is translational regulator of BRAF synthesis/ubiquitination, since BRAF down-regulation, ERK signaling inhibition and delay of cell cycle progression occur upon TRAP1 silencing/inhibition. Since TRAP1 is upregulated in human colorectal carcinomas (CRCs) and involved in prot...

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Detalles Bibliográficos
Autores principales: Condelli, Valentina, Maddalena, Francesca, Sisinni, Lorenza, Lettini, Giacomo, Matassa, Danilo Swann, Piscazzi, Annamaria, Palladino, Giuseppe, Amoroso, Maria Rosaria, Esposito, Franca, Landriscina, Matteo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4673164/
https://www.ncbi.nlm.nih.gov/pubmed/26084290

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