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Similar but different: distinct roles for KRAS and BRAF oncogenes in colorectal cancer development and therapy resistance

Colorectal cancer (CRC) is characterized by recurrent mutations deregulating key cell signaling cascades and providing the cancer cells with novel functional traits. Among the most frequent mutations in CRC are gain-of-function missense mutations in KRAS and BRAF. Oncogenic activation of KRAS and BR...

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Detalles Bibliográficos
Autores principales:	Morkel, Markus, Riemer, Pamela, Bläker, Hendrik, Sers, Christine
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2015
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4673229/ https://www.ncbi.nlm.nih.gov/pubmed/26299805

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