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Pharmacological inactivation of CHK1 and WEE1 induces mitotic catastrophe in nasopharyngeal carcinoma cells

Nasopharyngeal carcinoma (NPC) is a rare but highly invasive cancer. As radiotherapy is the primary treatment for NPC, this offers a rationale to investigate if uncoupling the DNA damage responses can sensitize this cancer type. The G(2) DNA damage checkpoint is controlled by a cascade of protein ki...

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Detalles Bibliográficos
Autores principales:	Mak, Joyce P.Y., Man, Wing Yu, Chow, Jeremy P.H., Ma, Hoi Tang, Poon, Randy Y.C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2015
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4673251/ https://www.ncbi.nlm.nih.gov/pubmed/26025928

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