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Novel HER3/MUC4 oncogenic signaling aggravates the tumorigenic phenotypes of pancreatic cancer cells

Several studies have demonstrated that MUC4 is involved in progression and metastasis of pancreatic cancer (PC). Here, we report that HER3/MUC4 interaction in HER2 low cells is critical in driving pancreatic tumorigenesis. Upon HER2 knockdown, we observed elevated expression of HER3 and MUC4 and the...

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Detalles Bibliográficos
Autores principales:	Lakshmanan, Imayavaramban, Seshacharyulu, Parthasarathy, Haridas, Dhanya, Rachagani, Satyanarayana, Gupta, Suprit, Joshi, Suhasini, Guda, Chittibabu, Yan, Ying, Jain, Maneesh, Ganti, Apar K., Ponnusamy, Moorthy P., Batra, Surinder K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2015
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4673252/ https://www.ncbi.nlm.nih.gov/pubmed/26035354

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