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The peroxisome proliferator activated receptor gamma agonist pioglitazone increases functional expression of the glutamate transporter excitatory amino acid transporter 2 (EAAT2) in human glioblastoma cells
Glioma cells release glutamate through expression of system x(c)(−), which exchanges intracellular glutamate for extracellular cysteine. Lack of the excitatory amino acid transporter 2 (EAAT2) expression maintains high extracellular glutamate levels in the glioma microenvironment, causing excitotoxi...
Autores principales: | Ching, Jared, Amiridis, Stephanie, Stylli, Stanley S., Bjorksten, Andrew R., Kountouri, Nicole, Zheng, Thomas, Paradiso, Lucy, Luwor, Rodney B., Morokoff, Andrew P., O'Brien, Terence J., Kaye, Andrew H. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4673266/ https://www.ncbi.nlm.nih.gov/pubmed/26046374 |
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