CXCR1/2 antagonism with CXCL8/Interleukin-8 analogue CXCL8((3–72))K11R/G31P restricts lung cancer growth by inhibiting tumor cell proliferation and suppressing angiogenesis

CXCR1 and CXCR2 together with cognate chemokines are significantly upregulated in a number of cancers, where they act as key regulators of tumor cell proliferation, metastasis, and angiogenesis. We have previously reported a mutant protein of CXCL8/Interleukin-8, CXCL8((3–72))K11R/G31P (G31P), which...

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Detalles Bibliográficos
Autores principales: Khan, Muhammad Noman, Wang, Bing, Wei, Jing, Zhang, Yingqiu, Li, Qiang, Luan, Xuelin, Cheng, Jya-Wei, Gordon, John R., Li, Fang, Liu, Han
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4673267/
https://www.ncbi.nlm.nih.gov/pubmed/26087179

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