A fully human chimeric antigen receptor with potent activity against cancer cells but reduced risk for off-tumor toxicity

Chimeric antigen receptors (CARs) can redirect T cells against antigen-expressing tumors in an HLA-independent manner. To date, various CARs have been constructed using mouse single chain antibody variable fragments (scFvs) of high affinity that are immunogenic in humans and have the potential to me...

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Detalles Bibliográficos
Autores principales: Song, De-Gang, Ye, Qunrui, Poussin, Mathilde, Liu, Lin, Figini, Mariangela, Powell, Daniel J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4673284/
https://www.ncbi.nlm.nih.gov/pubmed/26101914

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4673284/
https://www.ncbi.nlm.nih.gov/pubmed/26101914

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