siRNAs with decreased off-target effect facilitate the identification of essential genes in cancer cells

Since the essential genes are crucial to the proliferation and survival of cancer cells, the interference of these genes is promising to be an option for cancer therapy to overcome heterogeneity. However, the essential genes are highly overestimated by RNA interference (RNAi) screenings, which is ma...

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Detalles Bibliográficos
Autores principales: Li, Chunyan, Liu, Zhenzhen, Yang, Fang, Liu, Wensheng, Wang, Di, Dong, Encheng, Wang, Yu, Wu, Chung-I, Lu, Xuemei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4673289/
https://www.ncbi.nlm.nih.gov/pubmed/26057633

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