Cargando…

Dyskerin and TERC expression may condition survival in lung cancer patients

Dyskerin mediates both the modification of uridine on ribosomal and small nuclear RNAs and the stabilization of the telomerase RNA component (TERC). In human tumors dyskerin expression was found to be associated with both rRNA modification and TERC levels. Moreover, dyskerin overexpression has been...

Descripción completa

Detalles Bibliográficos
Autores principales:	Penzo, Marianna, Ludovini, Vienna, Treré, Davide, Siggillino, Annamaria, Vannucci, Jacopo, Bellezza, Guido, Crinò, Lucio, Montanaro, Lorenzo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2015
Materias:	Clinical Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4673301/ https://www.ncbi.nlm.nih.gov/pubmed/26301749

Ejemplares similares

Dyskerin depletion increases VEGF mRNA internal ribosome entry site-mediated translation
por: Rocchi, Laura, et al.
Publicado: (2013)

Gene identification for risk of relapse in stage I lung adenocarcinoma patients: a combined methodology of gene expression profiling and computational gene network analysis
por: Ludovini, Vienna, et al.
Publicado: (2016)

Relationship between Dyskerin Expression and Telomerase Activity in Human Breast Cancer
por: Montanaro, Lorenzo, et al.
Publicado: (2008)

Human dyskerin binds to cytoplasmic H/ACA-box-containing transcripts affecting nuclear hormone receptor dependence
por: Zacchini, Federico, et al.
Publicado: (2022)

Functional signaling pathway analysis of lung adenocarcinomas identifies novel therapeutic targets for KRAS mutant tumors
por: Baldelli, Elisa, et al.
Publicado: (2015)

Reverse phase protein array (RPPA) combined with computational analysis to unravel relevant prognostic factors in non- small cell lung cancer (NSCLC): a pilot study
por: Ludovini, Vienna, et al.
Publicado: (2017)

Separated Siamese Twins: Intronic Small Nucleolar RNAs and Matched Host Genes May be Altered in Conjunction or Separately in Multiple Cancer Types
por: Penzo, Marianna, et al.
Publicado: (2020)

The Ribosome Biogenesis—Cancer Connection
por: Penzo, Marianna, et al.
Publicado: (2019)

High PD-L1/IDO-2 and PD-L2/IDO-1 Co-Expression Levels Are Associated with Worse Overall Survival in Resected Non-Small Cell Lung Cancer Patients
por: Ludovini, Vienna, et al.
Publicado: (2021)

Enteric-type adenocarcinoma of the lung harbouring a novel KRAS Q22K mutation with concomitant KRAS polysomy: a case report
por: Metro, Giulio, et al.
Publicado: (2015)

Inhibition of Human Dyskerin as a New Approach to Target Ribosome Biogenesis
por: Rocchi, Laura, et al.
Publicado: (2014)

RNA Pseudouridylation in Physiology and Medicine: For Better and for Worse
por: Penzo, Marianna, et al.
Publicado: (2017)

Erratum to: ‘Conditional robustness analysis for fragility discovery and target identification in biochemical networks and in cancer systems biology’
por: Bianconi, Fortunato, et al.
Publicado: (2016)

Detection of EGFR Mutations in Plasma Cell-Free Tumor DNA of TKI-Treated Advanced-NSCLC Patients by Three Methodologies: Scorpion-ARMS, PNAClamp, and Digital PCR
por: Siggillino, Annamaria, et al.
Publicado: (2020)

Drosophila dyskerin is required for somatic stem cell homeostasis
por: Vicidomini, Rosario, et al.
Publicado: (2017)

Kynurenine/Tryptophan Ratio as a Potential Blood-Based Biomarker in Non-Small Cell Lung Cancer
por: Mandarano, Martina, et al.
Publicado: (2021)

Higher TLR7 Gene Expression Predicts Poor Clinical Outcome in Advanced NSCLC Patients Treated with Immunotherapy
por: Baglivo, Sara, et al.
Publicado: (2021)

RET Rearrangement as a Predictor of Unresponsiveness to Immunotherapy in Non-Small Cell Lung Cancer: Report of Two Cases with Review of the Literature
por: Baglivo, Sara, et al.
Publicado: (2020)

The emerging role of RNA polymerase I transcription machinery in human malignancy: a clinical perspective
por: Montanaro, Lorenzo, et al.
Publicado: (2013)

Prognostic impact of alternative splicing-derived hMENA isoforms in resected, node-negative, non-small-cell lung cancer
por: Bria, Emilio, et al.
Publicado: (2014)

Control of protein synthesis through mRNA pseudouridylation by dyskerin
por: Pederiva, Chiara, et al.
Publicado: (2023)

Epigenetic up-regulation of ribosome biogenesis and more aggressive phenotype triggered by the lack of the histone demethylase JHDM1B in mammary epithelial cells
por: Galbiati, Alice, et al.
Publicado: (2017)

SnoRNA U50 Levels Are Regulated by Cell Proliferation and rRNA Transcription
por: Pacilli, Annalisa, et al.
Publicado: (2013)

Aberrant Dyskerin Expression Is Related to Proliferation and Poor Survival in Endometrial Cancer
por: Alnafakh, Rafah, et al.
Publicado: (2021)

The nucleolar size is associated to the methylation status of ribosomal DNA in breast carcinomas
por: Bacalini, Maria Giulia, et al.
Publicado: (2014)

A functional connection between dyskerin and energy metabolism
por: Angrisani, Alberto, et al.
Publicado: (2017)

A new role for human dyskerin in vesicular trafficking
por: Di Maio, Nunzia, et al.
Publicado: (2017)

Indoleamine 2,3-Dioxygenase 2 Immunohistochemical Expression in Resected Human Non-small Cell Lung Cancer: A Potential New Prognostic Tool
por: Mandarano, Martina, et al.
Publicado: (2020)

CYP17, GSTP1, PON1 and GLO1 gene polymorphisms as risk factors for breast cancer: an Italian case-control study
por: Antognelli, Cinzia, et al.
Publicado: (2009)

SMN and coilin negatively regulate dyskerin association with telomerase RNA
por: Poole, Aaron R., et al.
Publicado: (2016)

Sex differences in telomere length, lifespan, and embryonic dyskerin levels
por: Lansdorp, Peter M.
Publicado: (2022)

Primer extension coupled with fragment analysis for rapid and quantitative evaluation of 5.8S rRNA isoforms
por: Venturi, Giulia, et al.
Publicado: (2021)

Sensitivity to Immune Checkpoint Blockade in Advanced Non-Small Cell Lung Cancer Patients with EGFR Exon 20 Insertion Mutations
por: Metro, Giulio, et al.
Publicado: (2021)

Dyskerin Localizes to the Mitotic Apparatus and Is Required for Orderly Mitosis in Human Cells
por: Alawi, Faizan, et al.
Publicado: (2013)

Loss of dyskerin facilitates the acquisition of metastatic traits by altering the mevalonate pathway
por: Andrades, Evelyn, et al.
Publicado: (2023)

New Insights into Dyskerin-CypA Interaction: Implications for X-Linked Dyskeratosis Congenita and Beyond
por: Belli, Valentina, et al.
Publicado: (2023)

Turning Uridines around: Role of rRNA Pseudouridylation in Ribosome Biogenesis and Ribosomal Function
por: Penzo, Marianna, et al.
Publicado: (2018)

DKC1 Overexpression Induces a More Aggressive Cellular Behavior and Increases Intrinsic Ribosomal Activity in Immortalized Mammary Gland Cells
por: Guerrieri, Ania Naila, et al.
Publicado: (2020)

TERC promotes cellular inflammatory response independent of telomerase
por: Liu, Haiying, et al.
Publicado: (2019)

Observational analysis on inflammatory reaction to talc pleurodesis: Small and large animal model series review
por: Vannucci, Jacopo, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_3jgahbe1d4dfeive0ssf8urvbo