Eosinophils Reduce Chronic Inflammation in Adipose Tissue by Secreting Th2 Cytokines and Promoting M2 Macrophages Polarization

Obesity is now recognized as a low-grade, chronic inflammatory disease that is linked to a myriad of disorders including cardiovascular diseases, type 2 diabetes, and liver diseases. Recently it is found that eosinophils accelerate alternative activation macrophage (AAM) polarization by secreting Th...

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Detalles Bibliográficos
Autores principales: Zhang, Yi, Yang, Peng, Cui, Ran, Zhang, Manna, Li, Hong, Qian, Chunhua, Sheng, Chunjun, Qu, Shen, Bu, Le
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4673347/
https://www.ncbi.nlm.nih.gov/pubmed/26688684
http://dx.doi.org/10.1155/2015/565760
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author Zhang, Yi
Yang, Peng
Cui, Ran
Zhang, Manna
Li, Hong
Qian, Chunhua
Sheng, Chunjun
Qu, Shen
Bu, Le
author_facet Zhang, Yi
Yang, Peng
Cui, Ran
Zhang, Manna
Li, Hong
Qian, Chunhua
Sheng, Chunjun
Qu, Shen
Bu, Le
author_sort Zhang, Yi
collection PubMed
description Obesity is now recognized as a low-grade, chronic inflammatory disease that is linked to a myriad of disorders including cardiovascular diseases, type 2 diabetes, and liver diseases. Recently it is found that eosinophils accelerate alternative activation macrophage (AAM) polarization by secreting Th2 type cytokines such as interleukin-4 and interleukin-13, thereby reducing metainflammation in adipose tissue. In this review, we focused on the role of eosinophils in regulating metabolic homeostasis and obesity.
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spelling pubmed-46733472015-12-20 Eosinophils Reduce Chronic Inflammation in Adipose Tissue by Secreting Th2 Cytokines and Promoting M2 Macrophages Polarization Zhang, Yi Yang, Peng Cui, Ran Zhang, Manna Li, Hong Qian, Chunhua Sheng, Chunjun Qu, Shen Bu, Le Int J Endocrinol Review Article Obesity is now recognized as a low-grade, chronic inflammatory disease that is linked to a myriad of disorders including cardiovascular diseases, type 2 diabetes, and liver diseases. Recently it is found that eosinophils accelerate alternative activation macrophage (AAM) polarization by secreting Th2 type cytokines such as interleukin-4 and interleukin-13, thereby reducing metainflammation in adipose tissue. In this review, we focused on the role of eosinophils in regulating metabolic homeostasis and obesity. Hindawi Publishing Corporation 2015 2015-11-25 /pmc/articles/PMC4673347/ /pubmed/26688684 http://dx.doi.org/10.1155/2015/565760 Text en Copyright © 2015 Yi Zhang et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Zhang, Yi
Yang, Peng
Cui, Ran
Zhang, Manna
Li, Hong
Qian, Chunhua
Sheng, Chunjun
Qu, Shen
Bu, Le
Eosinophils Reduce Chronic Inflammation in Adipose Tissue by Secreting Th2 Cytokines and Promoting M2 Macrophages Polarization
title Eosinophils Reduce Chronic Inflammation in Adipose Tissue by Secreting Th2 Cytokines and Promoting M2 Macrophages Polarization
title_full Eosinophils Reduce Chronic Inflammation in Adipose Tissue by Secreting Th2 Cytokines and Promoting M2 Macrophages Polarization
title_fullStr Eosinophils Reduce Chronic Inflammation in Adipose Tissue by Secreting Th2 Cytokines and Promoting M2 Macrophages Polarization
title_full_unstemmed Eosinophils Reduce Chronic Inflammation in Adipose Tissue by Secreting Th2 Cytokines and Promoting M2 Macrophages Polarization
title_short Eosinophils Reduce Chronic Inflammation in Adipose Tissue by Secreting Th2 Cytokines and Promoting M2 Macrophages Polarization
title_sort eosinophils reduce chronic inflammation in adipose tissue by secreting th2 cytokines and promoting m2 macrophages polarization
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4673347/
https://www.ncbi.nlm.nih.gov/pubmed/26688684
http://dx.doi.org/10.1155/2015/565760
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