Synthesis and Biological Evaluation of New Hydrazone Derivatives of Quinoline and Their Cu(II) and Zn(II) Complexes against Mycobacterium tuberculosis

A new series of quinoline hydrazone derivatives and their metal complexes have been synthesized and their biological properties have been evaluated against Mycobacterium tuberculosis (H37 RV strain). Most of the newly synthesized compounds displayed 100% inhibitory activity at a concentration of 6.2...

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Detalles Bibliográficos
Autores principales: Mandewale, Mustapha C., Thorat, Bapu, Shelke, Dnyaneshwar, Yamgar, Ramesh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4673354/
https://www.ncbi.nlm.nih.gov/pubmed/26759537
http://dx.doi.org/10.1155/2015/153015
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author Mandewale, Mustapha C.
Thorat, Bapu
Shelke, Dnyaneshwar
Yamgar, Ramesh
author_facet Mandewale, Mustapha C.
Thorat, Bapu
Shelke, Dnyaneshwar
Yamgar, Ramesh
author_sort Mandewale, Mustapha C.
collection PubMed
description A new series of quinoline hydrazone derivatives and their metal complexes have been synthesized and their biological properties have been evaluated against Mycobacterium tuberculosis (H37 RV strain). Most of the newly synthesized compounds displayed 100% inhibitory activity at a concentration of 6.25–25 μg/mL, against Mycobacterium tuberculosis. Fluorescence properties of all the synthesized compounds have been studied.
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spelling pubmed-46733542016-01-12 Synthesis and Biological Evaluation of New Hydrazone Derivatives of Quinoline and Their Cu(II) and Zn(II) Complexes against Mycobacterium tuberculosis Mandewale, Mustapha C. Thorat, Bapu Shelke, Dnyaneshwar Yamgar, Ramesh Bioinorg Chem Appl Research Article A new series of quinoline hydrazone derivatives and their metal complexes have been synthesized and their biological properties have been evaluated against Mycobacterium tuberculosis (H37 RV strain). Most of the newly synthesized compounds displayed 100% inhibitory activity at a concentration of 6.25–25 μg/mL, against Mycobacterium tuberculosis. Fluorescence properties of all the synthesized compounds have been studied. Hindawi Publishing Corporation 2015 2015-11-25 /pmc/articles/PMC4673354/ /pubmed/26759537 http://dx.doi.org/10.1155/2015/153015 Text en Copyright © 2015 Mustapha C. Mandewale et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Mandewale, Mustapha C.
Thorat, Bapu
Shelke, Dnyaneshwar
Yamgar, Ramesh
Synthesis and Biological Evaluation of New Hydrazone Derivatives of Quinoline and Their Cu(II) and Zn(II) Complexes against Mycobacterium tuberculosis
title Synthesis and Biological Evaluation of New Hydrazone Derivatives of Quinoline and Their Cu(II) and Zn(II) Complexes against Mycobacterium tuberculosis
title_full Synthesis and Biological Evaluation of New Hydrazone Derivatives of Quinoline and Their Cu(II) and Zn(II) Complexes against Mycobacterium tuberculosis
title_fullStr Synthesis and Biological Evaluation of New Hydrazone Derivatives of Quinoline and Their Cu(II) and Zn(II) Complexes against Mycobacterium tuberculosis
title_full_unstemmed Synthesis and Biological Evaluation of New Hydrazone Derivatives of Quinoline and Their Cu(II) and Zn(II) Complexes against Mycobacterium tuberculosis
title_short Synthesis and Biological Evaluation of New Hydrazone Derivatives of Quinoline and Their Cu(II) and Zn(II) Complexes against Mycobacterium tuberculosis
title_sort synthesis and biological evaluation of new hydrazone derivatives of quinoline and their cu(ii) and zn(ii) complexes against mycobacterium tuberculosis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4673354/
https://www.ncbi.nlm.nih.gov/pubmed/26759537
http://dx.doi.org/10.1155/2015/153015
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