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Sphingolipids as Regulators of the Phagocytic Response to Fungal Infections

Fungal infections pose a significant risk for the increasing population of individuals who are immunocompromised. Phagocytes play an important role in immune defense against fungal pathogens, but the interactions between host and fungi are still not well understood. Sphingolipids have been shown to...

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Detalles Bibliográficos
Autores principales: Bryan, Arielle M., Del Poeta, Maurizio, Luberto, Chiara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4673356/
https://www.ncbi.nlm.nih.gov/pubmed/26688618
http://dx.doi.org/10.1155/2015/640540
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author Bryan, Arielle M.
Del Poeta, Maurizio
Luberto, Chiara
author_facet Bryan, Arielle M.
Del Poeta, Maurizio
Luberto, Chiara
author_sort Bryan, Arielle M.
collection PubMed
description Fungal infections pose a significant risk for the increasing population of individuals who are immunocompromised. Phagocytes play an important role in immune defense against fungal pathogens, but the interactions between host and fungi are still not well understood. Sphingolipids have been shown to play an important role in many cell functions, including the function of phagocytes. In this review, we discuss major findings that relate to the importance of sphingolipids in macrophage and neutrophil function and the role of macrophages and neutrophils in the most common types of fungal infections, as well as studies that have linked these three concepts to show the importance of sphingolipid signaling in immune response to fungal infections.
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spelling pubmed-46733562015-12-20 Sphingolipids as Regulators of the Phagocytic Response to Fungal Infections Bryan, Arielle M. Del Poeta, Maurizio Luberto, Chiara Mediators Inflamm Review Article Fungal infections pose a significant risk for the increasing population of individuals who are immunocompromised. Phagocytes play an important role in immune defense against fungal pathogens, but the interactions between host and fungi are still not well understood. Sphingolipids have been shown to play an important role in many cell functions, including the function of phagocytes. In this review, we discuss major findings that relate to the importance of sphingolipids in macrophage and neutrophil function and the role of macrophages and neutrophils in the most common types of fungal infections, as well as studies that have linked these three concepts to show the importance of sphingolipid signaling in immune response to fungal infections. Hindawi Publishing Corporation 2015 2015-11-25 /pmc/articles/PMC4673356/ /pubmed/26688618 http://dx.doi.org/10.1155/2015/640540 Text en Copyright © 2015 Arielle M. Bryan et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Bryan, Arielle M.
Del Poeta, Maurizio
Luberto, Chiara
Sphingolipids as Regulators of the Phagocytic Response to Fungal Infections
title Sphingolipids as Regulators of the Phagocytic Response to Fungal Infections
title_full Sphingolipids as Regulators of the Phagocytic Response to Fungal Infections
title_fullStr Sphingolipids as Regulators of the Phagocytic Response to Fungal Infections
title_full_unstemmed Sphingolipids as Regulators of the Phagocytic Response to Fungal Infections
title_short Sphingolipids as Regulators of the Phagocytic Response to Fungal Infections
title_sort sphingolipids as regulators of the phagocytic response to fungal infections
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4673356/
https://www.ncbi.nlm.nih.gov/pubmed/26688618
http://dx.doi.org/10.1155/2015/640540
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