miR-139 modulates MCPIP1/IL-6 expression and induces apoptosis in human OA chondrocytes

IL-6 is an inflammatory cytokine and its overexpression plays an important role in osteoarthritis (OA) pathogenesis. Expression of IL-6 is regulated post-transcriptionally by MCPIP1. The 3′ untranslated region (UTR) of MCPIP1 mRNA harbors a miR-139 ‘seed sequence', therefore we examined the pos...

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Detalles Bibliográficos
Autores principales: Makki, Mohammad Shahidul, Haqqi, Tariq M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4673474/
https://www.ncbi.nlm.nih.gov/pubmed/26450708
http://dx.doi.org/10.1038/emm.2015.66

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4673474/
https://www.ncbi.nlm.nih.gov/pubmed/26450708
http://dx.doi.org/10.1038/emm.2015.66

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