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miR-139 modulates MCPIP1/IL-6 expression and induces apoptosis in human OA chondrocytes
IL-6 is an inflammatory cytokine and its overexpression plays an important role in osteoarthritis (OA) pathogenesis. Expression of IL-6 is regulated post-transcriptionally by MCPIP1. The 3′ untranslated region (UTR) of MCPIP1 mRNA harbors a miR-139 ‘seed sequence', therefore we examined the pos...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group
2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4673474/ https://www.ncbi.nlm.nih.gov/pubmed/26450708 http://dx.doi.org/10.1038/emm.2015.66 |