Chemoselective N-Deacetylation of Protected Nucleosides and Nucleotides Promoted by Schwartz's Reagent

Protection and deprotection strategies involving the N-acetyl group are widely utilized in nucleoside and nucleotide chemistry. Herein, we present a mild and selective N-deacetylation methodology, applicable to purine and pyrimidine nucleosides, by means of Schwartz's reagent, compatible with m...

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Detalles Bibliográficos
Autores principales: Ferrari, Valentina, Serpi, Michaela, McGuigan, Christopher, Pertusati, Fabrizio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4673560/
https://www.ncbi.nlm.nih.gov/pubmed/26492555
http://dx.doi.org/10.1080/15257770.2015.1075552
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author Ferrari, Valentina
Serpi, Michaela
McGuigan, Christopher
Pertusati, Fabrizio
author_facet Ferrari, Valentina
Serpi, Michaela
McGuigan, Christopher
Pertusati, Fabrizio
author_sort Ferrari, Valentina
collection PubMed
description Protection and deprotection strategies involving the N-acetyl group are widely utilized in nucleoside and nucleotide chemistry. Herein, we present a mild and selective N-deacetylation methodology, applicable to purine and pyrimidine nucleosides, by means of Schwartz's reagent, compatible with most of the common protecting groups used in nucleoside chemistry.
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spelling pubmed-46735602015-12-15 Chemoselective N-Deacetylation of Protected Nucleosides and Nucleotides Promoted by Schwartz's Reagent Ferrari, Valentina Serpi, Michaela McGuigan, Christopher Pertusati, Fabrizio Nucleosides Nucleotides Nucleic Acids Original Articles Protection and deprotection strategies involving the N-acetyl group are widely utilized in nucleoside and nucleotide chemistry. Herein, we present a mild and selective N-deacetylation methodology, applicable to purine and pyrimidine nucleosides, by means of Schwartz's reagent, compatible with most of the common protecting groups used in nucleoside chemistry. Taylor & Francis 2015-11-02 2015-11-16 /pmc/articles/PMC4673560/ /pubmed/26492555 http://dx.doi.org/10.1080/15257770.2015.1075552 Text en © 2015 Christopher L. Brown, Elisabeth Criscuolo Urbinati, Weimin Zhang, Shannon B. Brown, and Michelle McComb-Kobza. Published with license by Taylor & Francis This is an Open Access article. Non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly attributed, cited, and is not altered, transformed, or built upon in any way, is permitted. The moral rights of the named author(s) have been asserted.
spellingShingle Original Articles
Ferrari, Valentina
Serpi, Michaela
McGuigan, Christopher
Pertusati, Fabrizio
Chemoselective N-Deacetylation of Protected Nucleosides and Nucleotides Promoted by Schwartz's Reagent
title Chemoselective N-Deacetylation of Protected Nucleosides and Nucleotides Promoted by Schwartz's Reagent
title_full Chemoselective N-Deacetylation of Protected Nucleosides and Nucleotides Promoted by Schwartz's Reagent
title_fullStr Chemoselective N-Deacetylation of Protected Nucleosides and Nucleotides Promoted by Schwartz's Reagent
title_full_unstemmed Chemoselective N-Deacetylation of Protected Nucleosides and Nucleotides Promoted by Schwartz's Reagent
title_short Chemoselective N-Deacetylation of Protected Nucleosides and Nucleotides Promoted by Schwartz's Reagent
title_sort chemoselective n-deacetylation of protected nucleosides and nucleotides promoted by schwartz's reagent
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4673560/
https://www.ncbi.nlm.nih.gov/pubmed/26492555
http://dx.doi.org/10.1080/15257770.2015.1075552
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