A Petal-type Chiral NADH Model: Design, Synthesis and its Asymmetric Reduction

A new type of NADH model compound has been synthesized by an efficient and convenient method. This model compound exhibits high reactivity and enantioselectivity in asymmetric reduction reactions. The results show that chiral NADH model S could be effectively combined with Mg(2+) to form ternary com...

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Detalles Bibliográficos
Autores principales: Bai, Cui-Bing, Wang, Nai-Xing, Wang, Yan-Jing, Xing, Yalan, Zhang, Wei, Lan, Xing-Wang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4673579/
https://www.ncbi.nlm.nih.gov/pubmed/26648413
http://dx.doi.org/10.1038/srep17458
Descripción
Sumario:A new type of NADH model compound has been synthesized by an efficient and convenient method. This model compound exhibits high reactivity and enantioselectivity in asymmetric reduction reactions. The results show that chiral NADH model S could be effectively combined with Mg(2+) to form ternary complexes. This novel C(3) symmetrical NADH model is capable of fluorescence emission at 460 nm when excited at 377 nm.

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