A Petal-type Chiral NADH Model: Design, Synthesis and its Asymmetric Reduction

A new type of NADH model compound has been synthesized by an efficient and convenient method. This model compound exhibits high reactivity and enantioselectivity in asymmetric reduction reactions. The results show that chiral NADH model S could be effectively combined with Mg(2+) to form ternary com...

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Detalles Bibliográficos
Autores principales: Bai, Cui-Bing, Wang, Nai-Xing, Wang, Yan-Jing, Xing, Yalan, Zhang, Wei, Lan, Xing-Wang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4673579/
https://www.ncbi.nlm.nih.gov/pubmed/26648413
http://dx.doi.org/10.1038/srep17458
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author Bai, Cui-Bing
Wang, Nai-Xing
Wang, Yan-Jing
Xing, Yalan
Zhang, Wei
Lan, Xing-Wang
author_facet Bai, Cui-Bing
Wang, Nai-Xing
Wang, Yan-Jing
Xing, Yalan
Zhang, Wei
Lan, Xing-Wang
author_sort Bai, Cui-Bing
collection PubMed
description A new type of NADH model compound has been synthesized by an efficient and convenient method. This model compound exhibits high reactivity and enantioselectivity in asymmetric reduction reactions. The results show that chiral NADH model S could be effectively combined with Mg(2+) to form ternary complexes. This novel C(3) symmetrical NADH model is capable of fluorescence emission at 460 nm when excited at 377 nm.
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spelling pubmed-46735792015-12-14 A Petal-type Chiral NADH Model: Design, Synthesis and its Asymmetric Reduction Bai, Cui-Bing Wang, Nai-Xing Wang, Yan-Jing Xing, Yalan Zhang, Wei Lan, Xing-Wang Sci Rep Article A new type of NADH model compound has been synthesized by an efficient and convenient method. This model compound exhibits high reactivity and enantioselectivity in asymmetric reduction reactions. The results show that chiral NADH model S could be effectively combined with Mg(2+) to form ternary complexes. This novel C(3) symmetrical NADH model is capable of fluorescence emission at 460 nm when excited at 377 nm. Nature Publishing Group 2015-12-09 /pmc/articles/PMC4673579/ /pubmed/26648413 http://dx.doi.org/10.1038/srep17458 Text en Copyright © 2015, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Bai, Cui-Bing
Wang, Nai-Xing
Wang, Yan-Jing
Xing, Yalan
Zhang, Wei
Lan, Xing-Wang
A Petal-type Chiral NADH Model: Design, Synthesis and its Asymmetric Reduction
title A Petal-type Chiral NADH Model: Design, Synthesis and its Asymmetric Reduction
title_full A Petal-type Chiral NADH Model: Design, Synthesis and its Asymmetric Reduction
title_fullStr A Petal-type Chiral NADH Model: Design, Synthesis and its Asymmetric Reduction
title_full_unstemmed A Petal-type Chiral NADH Model: Design, Synthesis and its Asymmetric Reduction
title_short A Petal-type Chiral NADH Model: Design, Synthesis and its Asymmetric Reduction
title_sort petal-type chiral nadh model: design, synthesis and its asymmetric reduction
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4673579/
https://www.ncbi.nlm.nih.gov/pubmed/26648413
http://dx.doi.org/10.1038/srep17458
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