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Sigh-induced changes of breathing pattern in preterm infants

Sighs are thought to play an important role in control of breathing. It is unclear how sighs are triggered, and whether preterm birth and lung disease influence breathing pattern prior to and after a sigh in infants. To assess whether frequency, morphology, size, and short-term variability in tidal...

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Autores principales: Jost, Kerstin, Latzin, Philipp, Fouzas, Sotirios, Proietti, Elena, Delgado-Eckert, Edgar W, Frey, Urs, Schulzke, Sven M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4673642/
https://www.ncbi.nlm.nih.gov/pubmed/26564066
http://dx.doi.org/10.14814/phy2.12613
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author Jost, Kerstin
Latzin, Philipp
Fouzas, Sotirios
Proietti, Elena
Delgado-Eckert, Edgar W
Frey, Urs
Schulzke, Sven M
author_facet Jost, Kerstin
Latzin, Philipp
Fouzas, Sotirios
Proietti, Elena
Delgado-Eckert, Edgar W
Frey, Urs
Schulzke, Sven M
author_sort Jost, Kerstin
collection PubMed
description Sighs are thought to play an important role in control of breathing. It is unclear how sighs are triggered, and whether preterm birth and lung disease influence breathing pattern prior to and after a sigh in infants. To assess whether frequency, morphology, size, and short-term variability in tidal volume (V(T)) before, during, and after a sigh are influenced by gestational age at birth and lung disease (bronchopulmonary dysplasia, BPD) in former preterm infants and healthy term controls measured at equivalent postconceptional age (PCA). We performed tidal breathing measurements in 143 infants during quiet natural sleep at a mean (SD) PCA of 44.8 (1.3) weeks. A total of 233 sighs were analyzed using multilevel, multivariable regression. Sigh frequency in preterm infants increased with the degree of prematurity and severity of BPD, but was not different from that of term controls when normalized to respiratory rate. After a sigh, V(T) decreased remarkably in all infants (paired t-test: P < 0.001). There was no major effect of prematurity or BPD on various indices of sigh morphology and changes in V(T) prior to or after a sigh. Short-term variability in V(T) modestly increased with maturity at birth and infants with BPD showed an earlier return to baseline variability in V(T) following a sigh. In early infancy, sigh-induced changes in breathing pattern are moderately influenced by prematurity and BPD in preterm infants. The major determinants of sigh-related breathing pattern in these infants remain to be investigated, ideally using a longitudinal study design.
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spelling pubmed-46736422015-12-15 Sigh-induced changes of breathing pattern in preterm infants Jost, Kerstin Latzin, Philipp Fouzas, Sotirios Proietti, Elena Delgado-Eckert, Edgar W Frey, Urs Schulzke, Sven M Physiol Rep Original Research Sighs are thought to play an important role in control of breathing. It is unclear how sighs are triggered, and whether preterm birth and lung disease influence breathing pattern prior to and after a sigh in infants. To assess whether frequency, morphology, size, and short-term variability in tidal volume (V(T)) before, during, and after a sigh are influenced by gestational age at birth and lung disease (bronchopulmonary dysplasia, BPD) in former preterm infants and healthy term controls measured at equivalent postconceptional age (PCA). We performed tidal breathing measurements in 143 infants during quiet natural sleep at a mean (SD) PCA of 44.8 (1.3) weeks. A total of 233 sighs were analyzed using multilevel, multivariable regression. Sigh frequency in preterm infants increased with the degree of prematurity and severity of BPD, but was not different from that of term controls when normalized to respiratory rate. After a sigh, V(T) decreased remarkably in all infants (paired t-test: P < 0.001). There was no major effect of prematurity or BPD on various indices of sigh morphology and changes in V(T) prior to or after a sigh. Short-term variability in V(T) modestly increased with maturity at birth and infants with BPD showed an earlier return to baseline variability in V(T) following a sigh. In early infancy, sigh-induced changes in breathing pattern are moderately influenced by prematurity and BPD in preterm infants. The major determinants of sigh-related breathing pattern in these infants remain to be investigated, ideally using a longitudinal study design. John Wiley & Sons, Ltd 2015-11-12 /pmc/articles/PMC4673642/ /pubmed/26564066 http://dx.doi.org/10.14814/phy2.12613 Text en © 2015 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society. http://creativecommons.org/licenses/by/4.0/ This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Research
Jost, Kerstin
Latzin, Philipp
Fouzas, Sotirios
Proietti, Elena
Delgado-Eckert, Edgar W
Frey, Urs
Schulzke, Sven M
Sigh-induced changes of breathing pattern in preterm infants
title Sigh-induced changes of breathing pattern in preterm infants
title_full Sigh-induced changes of breathing pattern in preterm infants
title_fullStr Sigh-induced changes of breathing pattern in preterm infants
title_full_unstemmed Sigh-induced changes of breathing pattern in preterm infants
title_short Sigh-induced changes of breathing pattern in preterm infants
title_sort sigh-induced changes of breathing pattern in preterm infants
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4673642/
https://www.ncbi.nlm.nih.gov/pubmed/26564066
http://dx.doi.org/10.14814/phy2.12613
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