Control for stochastic sampling variation and qualitative sequencing error in next generation sequencing

BACKGROUND: Clinical implementation of Next-Generation Sequencing (NGS) is challenged by poor control for stochastic sampling, library preparation biases and qualitative sequencing error. To address these challenges we developed and tested two hypotheses. METHODS: Hypothesis 1: Analytical variation...

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Detalles Bibliográficos
Autores principales: Blomquist, Thomas, Crawford, Erin L., Yeo, Jiyoun, Zhang, Xiaolu, Willey, James C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4673681/
https://www.ncbi.nlm.nih.gov/pubmed/26693143
http://dx.doi.org/10.1016/j.bdq.2015.08.003

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