Study of oxidants and antioxidants in patients of acute myocardial infarction

BACKGROUND: Oxygen free radicals have become attractive candidates to explain injuries in ischemic heart. An association between raised serum uric acid concentration and increased cardiovascular risk has been recognized, however its role in acute myocardial infarction (AMI) is still unclear. Recently, zinc is also trying to establish its role in tissue injury and oxidative stress. MATERIALS AND METHODS: This cross-sectional study was carried on 75 AMI patients. 5 ml of blood was drawn from each patient within 6 h of AMI, to estimate plasma malondialdehyde (MDA), serum zinc, whole blood superoxide desmutase, serum uric acid, and whole blood glutathione peroxidase (GPx). The same biochemicals were also determined in 50 age and gender matched controls for comparison. RESULTS: We found significantly increased level of plasma MDA (5.649 ± 0.1780 vs. 2.757 ± 0.1623), serum uric acid (4.533 ± 0.1526 vs. 3.200 ± 0.1616) and significantly decreased levels of serum zinc (104.5 ± 1.874 vs. 115.3 ± 3.077), whole blood GPx (4599 ± 101.1 vs. 5519 ± 81.63) and superoxide desmutase (166.8 ± 1.896 vs. 188.3 ± 4.120). All the parameters studied also showed similar significant changes in male and female cases separately. CONCLUSION: Raised MDA and decreased zinc, glutathione peroxidase, and superoxide desmutase levels denote the increased oxidative stress. Even being a defense, uric acid is raised as it is abundantly present in our body. Thus, AMI exhibits oxidative stress dependent changes irrespective of gender.