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Subgroup identification for treatment selection in biomarker adaptive design
BACKGROUND: Advances in molecular technology have shifted new drug development toward targeted therapy for treatments expected to benefit subpopulations of patients. Adaptive signature design (ASD) has been proposed to identify the most suitable target patient subgroup to enhance efficacy of treatme...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4673750/ https://www.ncbi.nlm.nih.gov/pubmed/26646831 http://dx.doi.org/10.1186/s12874-015-0098-7 |