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Tackling dengue fever: Current status and challenges
According to recent statistics, 96 million apparent dengue infections were estimated worldwide in 2010. This figure is by far greater than the WHO prediction which indicates the rapid spread of this disease posing a growing threat to the economy and a major challenge to clinicians and health care se...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4673751/ https://www.ncbi.nlm.nih.gov/pubmed/26645066 http://dx.doi.org/10.1186/s12985-015-0444-8 |
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author | Nedjadi, Taoufik El-Kafrawy, Sherif Sohrab, Sayed S. Desprès, Philippe Damanhouri, Ghazi Azhar, Esam |
author_facet | Nedjadi, Taoufik El-Kafrawy, Sherif Sohrab, Sayed S. Desprès, Philippe Damanhouri, Ghazi Azhar, Esam |
author_sort | Nedjadi, Taoufik |
collection | PubMed |
description | According to recent statistics, 96 million apparent dengue infections were estimated worldwide in 2010. This figure is by far greater than the WHO prediction which indicates the rapid spread of this disease posing a growing threat to the economy and a major challenge to clinicians and health care services across the globe particularly in the affected areas. This article aims at bringing to light the current epidemiological and clinical status of the dengue fever. The relationship between genetic mutations, single nucleotide polymorphism (SNP) and the pathophysiology of disease progression will be put into perspective. It will also highlight the recent advances in dengue vaccine development. Thus far, a significant progress has been made in unraveling the risk factors and understanding the molecular pathogenesis associated with the disease. However, further insights in molecular features of the disease and the development of animal models will enormously help improving the therapeutic interventions and potentially contribute to finding new preventive measures for population at risk. |
format | Online Article Text |
id | pubmed-4673751 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-46737512015-12-10 Tackling dengue fever: Current status and challenges Nedjadi, Taoufik El-Kafrawy, Sherif Sohrab, Sayed S. Desprès, Philippe Damanhouri, Ghazi Azhar, Esam Virol J Review According to recent statistics, 96 million apparent dengue infections were estimated worldwide in 2010. This figure is by far greater than the WHO prediction which indicates the rapid spread of this disease posing a growing threat to the economy and a major challenge to clinicians and health care services across the globe particularly in the affected areas. This article aims at bringing to light the current epidemiological and clinical status of the dengue fever. The relationship between genetic mutations, single nucleotide polymorphism (SNP) and the pathophysiology of disease progression will be put into perspective. It will also highlight the recent advances in dengue vaccine development. Thus far, a significant progress has been made in unraveling the risk factors and understanding the molecular pathogenesis associated with the disease. However, further insights in molecular features of the disease and the development of animal models will enormously help improving the therapeutic interventions and potentially contribute to finding new preventive measures for population at risk. BioMed Central 2015-12-09 /pmc/articles/PMC4673751/ /pubmed/26645066 http://dx.doi.org/10.1186/s12985-015-0444-8 Text en © Nedjadi et al. 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Review Nedjadi, Taoufik El-Kafrawy, Sherif Sohrab, Sayed S. Desprès, Philippe Damanhouri, Ghazi Azhar, Esam Tackling dengue fever: Current status and challenges |
title | Tackling dengue fever: Current status and challenges |
title_full | Tackling dengue fever: Current status and challenges |
title_fullStr | Tackling dengue fever: Current status and challenges |
title_full_unstemmed | Tackling dengue fever: Current status and challenges |
title_short | Tackling dengue fever: Current status and challenges |
title_sort | tackling dengue fever: current status and challenges |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4673751/ https://www.ncbi.nlm.nih.gov/pubmed/26645066 http://dx.doi.org/10.1186/s12985-015-0444-8 |
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