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Prevalence and clinical profile of celiac disease in children with type 1 diabetes mellitus

OBJECTIVE: To determine the prevalence of celiac disease (CD) in children with type 1 diabetes mellitus (TIDM) in follow-up in a Tertiary Care Referral Centre in Western India and to describe the clinical features indicative of CD in screened patients of TIDM. STUDY DESIGN: In this single center obs...

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Autores principales: Joshi, Rajesh, Madvariya, Monica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4673809/
https://www.ncbi.nlm.nih.gov/pubmed/26693431
http://dx.doi.org/10.4103/2230-8210.167555
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author Joshi, Rajesh
Madvariya, Monica
author_facet Joshi, Rajesh
Madvariya, Monica
author_sort Joshi, Rajesh
collection PubMed
description OBJECTIVE: To determine the prevalence of celiac disease (CD) in children with type 1 diabetes mellitus (TIDM) in follow-up in a Tertiary Care Referral Centre in Western India and to describe the clinical features indicative of CD in screened patients of TIDM. STUDY DESIGN: In this single center observational cross-sectional study, 71 children who were diagnosed with TIDM were subjected to screening for CD with tissue transglutaminase antibody testing. Those who tested positive were offered intestinal biopsy for the confirmation of diagnosis. Clinical profiles of both groups of patients were compared and manifestations of CD were delineated. RESULTS: The study revealed the prevalence of CD (based on serology) in children with Type 1 diabetes as 15.49%. The prevalence of biopsy-confirmed CD was 7.04%. Of the diagnosed CD patients, one-third were symptomatic at the time of screening while the majority was asymptomatic. The major clinical features indicative of CD were intestinal symptoms, anemia, rickets, and short stature. Autoimmune thyroid disease was prevalent in 29.6% of the patients with TIDM followed by CD. CONCLUSIONS: The high prevalence of CD in children with Type 1 diabetes emphasizes the need for routine screening programs to be in place for these high-risk populations. The clinical profile of patients with CD further elaborates the indicators of CD and the need to screen for them.
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spelling pubmed-46738092015-12-21 Prevalence and clinical profile of celiac disease in children with type 1 diabetes mellitus Joshi, Rajesh Madvariya, Monica Indian J Endocrinol Metab Original Article OBJECTIVE: To determine the prevalence of celiac disease (CD) in children with type 1 diabetes mellitus (TIDM) in follow-up in a Tertiary Care Referral Centre in Western India and to describe the clinical features indicative of CD in screened patients of TIDM. STUDY DESIGN: In this single center observational cross-sectional study, 71 children who were diagnosed with TIDM were subjected to screening for CD with tissue transglutaminase antibody testing. Those who tested positive were offered intestinal biopsy for the confirmation of diagnosis. Clinical profiles of both groups of patients were compared and manifestations of CD were delineated. RESULTS: The study revealed the prevalence of CD (based on serology) in children with Type 1 diabetes as 15.49%. The prevalence of biopsy-confirmed CD was 7.04%. Of the diagnosed CD patients, one-third were symptomatic at the time of screening while the majority was asymptomatic. The major clinical features indicative of CD were intestinal symptoms, anemia, rickets, and short stature. Autoimmune thyroid disease was prevalent in 29.6% of the patients with TIDM followed by CD. CONCLUSIONS: The high prevalence of CD in children with Type 1 diabetes emphasizes the need for routine screening programs to be in place for these high-risk populations. The clinical profile of patients with CD further elaborates the indicators of CD and the need to screen for them. Medknow Publications & Media Pvt Ltd 2015 /pmc/articles/PMC4673809/ /pubmed/26693431 http://dx.doi.org/10.4103/2230-8210.167555 Text en Copyright: © Indian Journal of Endocrinology and Metabolism http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution NonCommercial ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Original Article
Joshi, Rajesh
Madvariya, Monica
Prevalence and clinical profile of celiac disease in children with type 1 diabetes mellitus
title Prevalence and clinical profile of celiac disease in children with type 1 diabetes mellitus
title_full Prevalence and clinical profile of celiac disease in children with type 1 diabetes mellitus
title_fullStr Prevalence and clinical profile of celiac disease in children with type 1 diabetes mellitus
title_full_unstemmed Prevalence and clinical profile of celiac disease in children with type 1 diabetes mellitus
title_short Prevalence and clinical profile of celiac disease in children with type 1 diabetes mellitus
title_sort prevalence and clinical profile of celiac disease in children with type 1 diabetes mellitus
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4673809/
https://www.ncbi.nlm.nih.gov/pubmed/26693431
http://dx.doi.org/10.4103/2230-8210.167555
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