SUMOylation of TARBP2 regulates miRNA/siRNA efficiency

Small RNA-induced gene silencing is essential for post-transcriptional regulation of gene expression; however, it remains unclear how miRNA/siRNA efficiency is regulated. Here we show that TARBP2 is SUMOylated at K52, which can be enhanced by its phosphorylation. This modification can stabilize TARB...

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Detalles Bibliográficos
Autores principales: Chen, Cheng, Zhu, Changhong, Huang, Jian, Zhao, Xian, Deng, Rong, Zhang, Hailong, Dou, Jinzhuo, Chen, Qin, Xu, Ming, Yuan, Haihua, Wang, Yanli, Yu, Jianxiu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4673853/
https://www.ncbi.nlm.nih.gov/pubmed/26582366
http://dx.doi.org/10.1038/ncomms9899

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