Site-Specific Glycoconjugation of Protein via Bioorthogonal Tetrazine Cycloaddition with a Genetically Encoded trans-Cyclooctene or Bicyclononyne

Efficient access to proteins modified site-specifically with glycans is important in glycobiology and for therapeutic applications. Herein, we report a biocompatible protein glycoconjugation by inverse demand Diels–Alder reaction between tetrazine and trans-cyclooctene. Tetrazine functionalized glyc...

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Detalles Bibliográficos
Autores principales: Machida, Takuya, Lang, Kathrin, Xue, Lin, Chin, Jason W., Winssinger, Nicolas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4673905/
https://www.ncbi.nlm.nih.gov/pubmed/25897481
http://dx.doi.org/10.1021/acs.bioconjchem.5b00101

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4673905/
https://www.ncbi.nlm.nih.gov/pubmed/25897481
http://dx.doi.org/10.1021/acs.bioconjchem.5b00101

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