Cargando…

Development and Validation of an HPLC Method for Determination of Amifostine and/or Its Metabolite (WR-1065) In Human Plasma Using OPA Derivatization and UV Detection

A rapid, sensitive and reproducible HPLC method was developed and validated for the analysis of amifostine (AMF) and/or its metabolite, WR-1065 in human plasma. The method involves the alkylation of free sulfydryl group with iodoacetic acid followed by derivatization of the drug and its metabolite w...

Descripción completa

Detalles Bibliográficos
Autores principales:	Samiei, Nasim, Foroutan, Seyed Mohsen, Shafaati, Alireza, Zarghi, Afshin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Shaheed Beheshti University of Medical Sciences 2015
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4673932/ https://www.ncbi.nlm.nih.gov/pubmed/26664371

Ejemplares similares

Sensitive and Rapid HPLC Method for Determination of Memantine in Human Plasma Using OPA Derivatization and Fluorescence Detection: Application to Pharmacokinetic Studies
por: Zarghi, Afshin, et al.
Publicado: (2010)

Antiretroviral activity of aminothiols, WR2721 and WR1065
por: Poirier, Miriam C, et al.
Publicado: (2006)

Effect of WR-1065 on 6-hydroxydopamine-induced catalepsy and IL-6 level in rats
por: Kheradmand, Afshin, et al.
Publicado: (2016)

Pharmacokinetics and Biodistribution of Pegylated Methotrexate after IV Administration to Mice
por: Yousefi, Gholamhossein, et al.
Publicado: (2018)

Conformational changes in chromatin structure induced by the radioprotective aminothiol, WR 1065.
por: Vaughan, A. T., et al.
Publicado: (1989)

Rapid High Performance Liquid Chromatographic Method for Determination of Clarithromycin in Human Plasma Using Amperometric Detection: Application in Pharmacokinetic and Bioequivalence Studies
por: Foroutan, Seyed Mohsen, et al.
Publicado: (2013)

Physicochemical, Stress Degradation Evaluation and Pharmacokinetic Study of AZGH101; a New Synthesized COX2 Inhibitor after I.V. and Oral Administration in Male and Female Rats
por: Bahmanof, Hoda, et al.
Publicado: (2018)

Physicochemical, Stress Degradation Evaluation and Pharmacokinetic Study of AZGH102, a New Synthesized COX2 Inhibitors after I.V. and Oral Administration in Male and Female Rats.
por: Bahmanof, Hoda, et al.
Publicado: (2017)

A Simple and Specific Stability- Indicating RP-HPLC Method for Routine Assay of Adefovir Dipivoxil in Bulk and Tablet Dosage Form
por: Darsazan, Bahar, et al.
Publicado: (2017)

Analysis of Aflatoxin B1 in Iranian Foods Using HPLC and a Monolithic Column and Estimation of its Dietary Intake
por: Yazdanpanah, Hassan, et al.
Publicado: (2013)

Occurrence of Deoxynivalenol in Foods for Human Consumption from Tehran, Iran
por: Yazdanpanah, Hassan, et al.
Publicado: (2014)

Optimal excitation and emission wavelengths to analyze amino acids and optimize neurotransmitters quantification using precolumn OPA-derivatization by HPLC
por: Perucho, J., et al.
Publicado: (2015)

WR1065 conjugated to thiol-PEG polymers as novel anticancer prodrugs: broad spectrum efficacy, synergism, and drug resistance reversal
por: Walker, Dale M., et al.
Publicado: (2023)

Beneficial effect of the oxygen free radical scavenger amifostine (WR-2721) on spinal cord ischemia/reperfusion injury in rabbits
por: Chronidou, Fany, et al.
Publicado: (2009)

The effect of 2-[(aminopropyl)amino] ethanethiol (WR-1065) on radiation induced DNA double strand damage and repair in V79 cells.
por: Sigdestad, C. P., et al.
Publicado: (1987)

The effect of 2-[(aminopropyl)amino] ethanethiol (WR1065) on radiation-induced DNA damage and repair and cell progression in V79 cells.
por: Grdina, D. J., et al.
Publicado: (1986)

Amifostine (WR-2721) Mitigates Cognitive Injury Induced by Heavy Ion Radiation in Male Mice and Alters Behavior and Brain Connectivity
por: Boutros, Sydney Weber, et al.
Publicado: (2021)

Handbook of derivatization reactions for HPLC /
por: Lunn, George
Publicado: (1998)

Antiretroviral activity of the aminothiol WR1065 against Human Immunodeficiency virus (HIV-1) in vitro and Simian Immunodeficiency virus (SIV) ex vivo
por: Poirier, Miriam C, et al.
Publicado: (2009)

Improvement of Capillary Electrophoretic Enantioseparation of Fluoxetine by a Cationic Additive
por: Sattary Javid, Farin, et al.
Publicado: (2013)

Application of Guanidine Hcl to Improve Enantioseparation of a Model Basic Drug, Cetirizine, By Capillary Electrophoresis Using Sulfated Β-Cyclodextrin
por: Shafaati, Alireza, et al.
Publicado: (2018)

Exposure Assessment of the Tehran Population (Iran) to Zearalenone Mycotoxin
por: Yazdanpanah, Hassan, et al.
Publicado: (2012)

A new HPLC-UV derivatization approach for the determination of potential genotoxic benzyl halides in drug substances
por: Ji, Shunli, et al.
Publicado: (2019)

Development of a Combined Solution Formulation of Atropine Sulfate and Obidoxime Chloride for Autoinjector and Evaluation of Its Stability
por: Ettehadi, Hossein Ali, et al.
Publicado: (2013)

Using HPLC with In-Column Derivatization to Authenticate Coffee Samples
por: Manwaring, Corey W., et al.
Publicado: (2023)

A Newly Developed HPLC-UV/Vis Method Using Chemical Derivatization with 2-Naphthalenethiol for Quantitation of Sulforaphane in Rat Plasma
por: Shin, Kyong-Oh, et al.
Publicado: (2021)

Alterations in Tissue Metabolite Profiles with Amifostine-Prophylaxed Mice Exposed to Gamma Radiation
por: Cheema, Amrita K., et al.
Publicado: (2020)

Frequency of Wr(a) antigen and anti-Wr(a) in Brazilian blood donors
por: Muniz, Janaína Guilhem, et al.
Publicado: (2015)

Development of an RP-HPLC-UV Method for Simultaneous Detection of Nimodipine and its Metabolite in Cerebrospinal Fluid of Rat
por: Sotoudegan, Farzaneh, et al.
Publicado: (2017)

Validation and Application of a Derivatization-Free RP-HPLC-DAD Method for the Determination of Low Molecular Weight Salivary Metabolites
por: Campanella, Beatrice, et al.
Publicado: (2020)

Determination of Formaldehyde by HPLC with Stable Precolumn Derivatization in Egyptian Dairy Products
por: Sebaei, Ahmed Salem, et al.
Publicado: (2018)

A Validated Reverse Phase HPLC Method for the Determination of Disodium EDTA in Meropenem Drug Substance with UV-Detection using Precolumn Derivatization Technique
por: Narola, Bhavil, et al.
Publicado: (2011)

Improvement of Electrophoretic Enantioseparation of Amlodipine by Polybrene
por: Zandkarimi, Majid, et al.
Publicado: (2012)

Synthesis and cytotoxicity of a biotinylated CC-1065 analogue
por: Wang, Yuqiang, et al.
Publicado: (2002)

Optimized Protocol for the In Situ Derivatization of Glutathione with N-Ethylmaleimide in Cultured Cells and the Simultaneous Determination of Glutathione/Glutathione Disulfide Ratio by HPLC-UV-QTOF-MS
por: Sun, Xueni, et al.
Publicado: (2020)

A New Derivatization Reagent for HPLC–MS Analysis of Biological Organic Acids
por: Marquis, Bryce J., et al.
Publicado: (2017)

Quantitative-Profiling Method of Serum Steroid Hormones by Hydroxylamine-Derivatization HPLC–MS
por: Liu, Qi, et al.
Publicado: (2019)

Serum Vitamin D Metabolites by HPLC-MS/MS Combined with Differential Ion Mobility Spectrometry: Aspects of Sample Preparation without Derivatization
por: Usoltseva, Liliia, et al.
Publicado: (2023)

A Validated Stability-indicating Reverse Phase HPLC Assay Method for the Determination of Memantine Hydrochloride Drug Substance with UV-Detection Using Precolumn Derivatization Technique
por: Narola, Bhavil, et al.
Publicado: (2010)

UV-protection from chitosan derivatized lignin multilayer thin film
por: Kolibaba, Thomas J., et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_fjsko325kebngnve3fn5dqmkgm