The Neuroprotective Effect of Lithium in cannabinoid Dependence is Mediated through Modulation of Cyclic AMP, ERK1/2 and GSK-3β Phosphorylation in Cerebellar Granular Neurons of Rat

Lithium (Li), a glycogen synthase kinase-3β (GSK-3β) inhibitor, has used to attenuate the cannabinoid-induced dependence/withdrawal signs, but molecular mechanisms related to this are unclear. Recent studies indicate the involvement of upstream extracellular signal kinase1/2 (ERK1/2) and downstream...

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Detalles Bibliográficos
Autores principales: Rahimi, Hamid Reza, Ghahremani, Mohammad Hossein, Dehpour, Ahmad Reza, Sharifzadeh, Mohammad, Ejtemaei-Mehr, Shahram, Razmi, Ali, Ostad, Seyed Nasser
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Shaheed Beheshti University of Medical Sciences 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4673940/
https://www.ncbi.nlm.nih.gov/pubmed/26664379

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