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TEM1 expression in cancer-associated fibroblasts is correlated with a poor prognosis in patients with gastric cancer
The cancer stroma, including cancer-associated fibroblasts (CAFs), is known to contribute to cancer cell progression and metastasis, suggesting that functional proteins expressed specifically in CAFs might be candidate molecular targets for cancer treatment. The purpose of the present study was to e...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley & Sons, Ltd
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4673993/ https://www.ncbi.nlm.nih.gov/pubmed/26336878 http://dx.doi.org/10.1002/cam4.515 |
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author | Fujii, Satoshi Fujihara, Ayano Natori, Kei Abe, Anna Kuboki, Yasutoshi Higuchi, Youichi Aizawa, Masaki Kuwata, Takeshi Kinoshita, Takahiro Yasui, Wataru Ochiai, Atsushi |
author_facet | Fujii, Satoshi Fujihara, Ayano Natori, Kei Abe, Anna Kuboki, Yasutoshi Higuchi, Youichi Aizawa, Masaki Kuwata, Takeshi Kinoshita, Takahiro Yasui, Wataru Ochiai, Atsushi |
author_sort | Fujii, Satoshi |
collection | PubMed |
description | The cancer stroma, including cancer-associated fibroblasts (CAFs), is known to contribute to cancer cell progression and metastasis, suggesting that functional proteins expressed specifically in CAFs might be candidate molecular targets for cancer treatment. The purpose of the present study was to explore the possibility of using TEM1 (tumor endothelial marker 1), which is known to be expressed in several types of mesenchymal cells, as a molecular target by examining the impact of TEM1 expression on clinicopathological factors in gastric cancer patients. A total of 945 consecutive patients with gastric cancer who underwent surgery at the National Cancer Center Hospital East between January 2003 and July 2007 were examined using a tissue microarray approach. TEM1 expression in CAFs or vessel-associated cells was determined using immunohistochemical staining. Three items (CAF-TEM1-positivity, CAF-TEM1-intensity, and vessel-TEM1-intensity) were then examined to determine the correlations between the TEM1 expression status and the recurrence-free survival (RFS), overall survival (OS), cancer-related survival (COS), and other clinicopathological factors. Significant correlations between CAF-TEM1-positivity or CAF-TEM1-intensity and RFS, OS, or COS were observed (P < 0.001, Kaplan–Meier curves); however, no significant correlation between vessel-TEM1-intensity and RFS, OS, or COS was observed. A univariate analysis showed that CAF-TEM1-positivity and CAF-TEM1-intensity were each correlated with a scirrhous subtype, tumor depth, nodal status, distant metastasis, serosal invasion, lymphatic or venous vessel infiltrations, and pTMN stage. This study suggests that the inhibition of TEM1 expression specifically in the CAFs of gastric carcinoma might represent a new strategy for the treatment of gastric cancer. |
format | Online Article Text |
id | pubmed-4673993 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | John Wiley & Sons, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-46739932015-12-16 TEM1 expression in cancer-associated fibroblasts is correlated with a poor prognosis in patients with gastric cancer Fujii, Satoshi Fujihara, Ayano Natori, Kei Abe, Anna Kuboki, Yasutoshi Higuchi, Youichi Aizawa, Masaki Kuwata, Takeshi Kinoshita, Takahiro Yasui, Wataru Ochiai, Atsushi Cancer Med Clinical Cancer Research The cancer stroma, including cancer-associated fibroblasts (CAFs), is known to contribute to cancer cell progression and metastasis, suggesting that functional proteins expressed specifically in CAFs might be candidate molecular targets for cancer treatment. The purpose of the present study was to explore the possibility of using TEM1 (tumor endothelial marker 1), which is known to be expressed in several types of mesenchymal cells, as a molecular target by examining the impact of TEM1 expression on clinicopathological factors in gastric cancer patients. A total of 945 consecutive patients with gastric cancer who underwent surgery at the National Cancer Center Hospital East between January 2003 and July 2007 were examined using a tissue microarray approach. TEM1 expression in CAFs or vessel-associated cells was determined using immunohistochemical staining. Three items (CAF-TEM1-positivity, CAF-TEM1-intensity, and vessel-TEM1-intensity) were then examined to determine the correlations between the TEM1 expression status and the recurrence-free survival (RFS), overall survival (OS), cancer-related survival (COS), and other clinicopathological factors. Significant correlations between CAF-TEM1-positivity or CAF-TEM1-intensity and RFS, OS, or COS were observed (P < 0.001, Kaplan–Meier curves); however, no significant correlation between vessel-TEM1-intensity and RFS, OS, or COS was observed. A univariate analysis showed that CAF-TEM1-positivity and CAF-TEM1-intensity were each correlated with a scirrhous subtype, tumor depth, nodal status, distant metastasis, serosal invasion, lymphatic or venous vessel infiltrations, and pTMN stage. This study suggests that the inhibition of TEM1 expression specifically in the CAFs of gastric carcinoma might represent a new strategy for the treatment of gastric cancer. John Wiley & Sons, Ltd 2015-11 2015-09-04 /pmc/articles/PMC4673993/ /pubmed/26336878 http://dx.doi.org/10.1002/cam4.515 Text en © 2015 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. http://creativecommons.org/licenses/by/4.0/ This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Clinical Cancer Research Fujii, Satoshi Fujihara, Ayano Natori, Kei Abe, Anna Kuboki, Yasutoshi Higuchi, Youichi Aizawa, Masaki Kuwata, Takeshi Kinoshita, Takahiro Yasui, Wataru Ochiai, Atsushi TEM1 expression in cancer-associated fibroblasts is correlated with a poor prognosis in patients with gastric cancer |
title | TEM1 expression in cancer-associated fibroblasts is correlated with a poor prognosis in patients with gastric cancer |
title_full | TEM1 expression in cancer-associated fibroblasts is correlated with a poor prognosis in patients with gastric cancer |
title_fullStr | TEM1 expression in cancer-associated fibroblasts is correlated with a poor prognosis in patients with gastric cancer |
title_full_unstemmed | TEM1 expression in cancer-associated fibroblasts is correlated with a poor prognosis in patients with gastric cancer |
title_short | TEM1 expression in cancer-associated fibroblasts is correlated with a poor prognosis in patients with gastric cancer |
title_sort | tem1 expression in cancer-associated fibroblasts is correlated with a poor prognosis in patients with gastric cancer |
topic | Clinical Cancer Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4673993/ https://www.ncbi.nlm.nih.gov/pubmed/26336878 http://dx.doi.org/10.1002/cam4.515 |
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