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Hypoxia-Targeted Drug Q6 Induces G2-M Arrest and Apoptosis via Poisoning Topoisomerase II under Hypoxia

In spite of the tremendous efforts dedicated to developing hypoxia-activated prodrugs, no agents yet have been approved for clinical therapy. In the present study, the hypoxic selective anti-cancer activity as well as the cellular target of a novel tirapazamine (TPZ) analogue, 7-methyl-3-(3-chloroph...

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Detalles Bibliográficos
Autores principales:	Chang, Linlin, Liu, Xiaowen, Wang, Dandan, Ma, Jian, Zhou, Tianyi, Chen, Ying, Sheng, Rong, Hu, Yongzhou, Du, Ying, He, Qiaojun, Yang, Bo, Zhu, Hong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4674137/ https://www.ncbi.nlm.nih.gov/pubmed/26649750 http://dx.doi.org/10.1371/journal.pone.0144506

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