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Isotonic Regression Based-Method in Quantitative High-Throughput Screenings for Genotoxicity

Quantitative high-throughput screenings (qHTSs) for genotoxicity are conducted as part of comprehensive toxicology screening projects. The most widely used method is to compare the dose-response data of a wild-type and DNA repair gene knockout mutants, using model-fitting to the Hill equation (HE)....

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Detalles Bibliográficos
Autores principales:	Fujii, Yosuke, Narita, Takeo, Tice, Raymond Richard, Takeda, Shunich, Yamada, Ryo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	SAGE Publications 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4674159/ https://www.ncbi.nlm.nih.gov/pubmed/26673567 http://dx.doi.org/10.2203/dose-response.13-045.Fujii

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