Commentary on Inhaled (239)PUO(2) in Dogs — A Prophylaxis Against Lung Cancer?

Several studies on the effect of inhaled plutonium-dioxide particulates and the incidence of lung tumors in dogs reveal beneficial effects when the cumulative alpha-radiation dose is low. There is a threshold at an exposure level of about 100 cGy for excess tumor incidence and reduced lifespan. The...

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Detalles Bibliográficos
Autores principales: Cuttler, Jerry M., Feinendegen, Ludwig E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4674170/
https://www.ncbi.nlm.nih.gov/pubmed/26675366
http://dx.doi.org/10.2203/dose-response.15-003.Cuttler
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author Cuttler, Jerry M.
Feinendegen, Ludwig E.
author_facet Cuttler, Jerry M.
Feinendegen, Ludwig E.
author_sort Cuttler, Jerry M.
collection PubMed
description Several studies on the effect of inhaled plutonium-dioxide particulates and the incidence of lung tumors in dogs reveal beneficial effects when the cumulative alpha-radiation dose is low. There is a threshold at an exposure level of about 100 cGy for excess tumor incidence and reduced lifespan. The observations conform to the expectations of the radiation hormesis dose-response model and contradict the predictions of the LNT hypothesis. These studies suggest investigating the possibility of employing low-dose alpha-radiation, such as from (239)PuO(2) inhalation, as a prophylaxis against lung cancer.
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spelling pubmed-46741702015-12-15 Commentary on Inhaled (239)PUO(2) in Dogs — A Prophylaxis Against Lung Cancer? Cuttler, Jerry M. Feinendegen, Ludwig E. Dose Response Article Several studies on the effect of inhaled plutonium-dioxide particulates and the incidence of lung tumors in dogs reveal beneficial effects when the cumulative alpha-radiation dose is low. There is a threshold at an exposure level of about 100 cGy for excess tumor incidence and reduced lifespan. The observations conform to the expectations of the radiation hormesis dose-response model and contradict the predictions of the LNT hypothesis. These studies suggest investigating the possibility of employing low-dose alpha-radiation, such as from (239)PuO(2) inhalation, as a prophylaxis against lung cancer. SAGE Publications 2015-05-04 /pmc/articles/PMC4674170/ /pubmed/26675366 http://dx.doi.org/10.2203/dose-response.15-003.Cuttler Text en © 2015 University of Massachusetts http://creativecommons.org/licenses/by-nc/3.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 3.0 License (http://www.creativecommons.org/licenses/by-nc/3.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (http://www.uk.sagepub.com/aboutus/openaccess.htm).
spellingShingle Article
Cuttler, Jerry M.
Feinendegen, Ludwig E.
Commentary on Inhaled (239)PUO(2) in Dogs — A Prophylaxis Against Lung Cancer?
title Commentary on Inhaled (239)PUO(2) in Dogs — A Prophylaxis Against Lung Cancer?
title_full Commentary on Inhaled (239)PUO(2) in Dogs — A Prophylaxis Against Lung Cancer?
title_fullStr Commentary on Inhaled (239)PUO(2) in Dogs — A Prophylaxis Against Lung Cancer?
title_full_unstemmed Commentary on Inhaled (239)PUO(2) in Dogs — A Prophylaxis Against Lung Cancer?
title_short Commentary on Inhaled (239)PUO(2) in Dogs — A Prophylaxis Against Lung Cancer?
title_sort commentary on inhaled (239)puo(2) in dogs — a prophylaxis against lung cancer?
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4674170/
https://www.ncbi.nlm.nih.gov/pubmed/26675366
http://dx.doi.org/10.2203/dose-response.15-003.Cuttler
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