Cargando…
Blood Pressure is Associated With Cerebral Blood Flow Alterations in Patients With T2DM as Revealed by Perfusion Functional MRI
Type 2 diabetes mellitus (T2DM) and hypertension are both associated with cognitive impairment and brain function abnormalities. We investigated whether abnormal cerebral blood flow (CBF) patterns exists in T2DM patients and possible relationships between aberrant CBF and cognitive performance. Furt...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer Health
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4674216/ https://www.ncbi.nlm.nih.gov/pubmed/26632913 http://dx.doi.org/10.1097/MD.0000000000002231 |
_version_ | 1782404882220711936 |
---|---|
author | Xia, Wenqing Rao, Hengyi Spaeth, Andrea M. Huang, Rong Tian, Sai Cai, Rongrong Sun, Jie Wang, Shaohua |
author_facet | Xia, Wenqing Rao, Hengyi Spaeth, Andrea M. Huang, Rong Tian, Sai Cai, Rongrong Sun, Jie Wang, Shaohua |
author_sort | Xia, Wenqing |
collection | PubMed |
description | Type 2 diabetes mellitus (T2DM) and hypertension are both associated with cognitive impairment and brain function abnormalities. We investigated whether abnormal cerebral blood flow (CBF) patterns exists in T2DM patients and possible relationships between aberrant CBF and cognitive performance. Furthermore, we examined the influence of hypertension on CBF alterations in T2DM patients. T2DM patients (n = 38) and non-T2DM subjects (n = 40) were recruited from clinics, hospitals, and normal community health screenings. Cerebral blood flow images were collected and analyzed using arterial spin labeling perfusion functional magnetic resonance imaging (fMRI). Regions with major CBF differences between T2DM patients and non-T2DM controls were detected via 1-way ANOVA. The interaction effects between hypertension and T2DM for CBF alterations were also examined. Correlation analyses illustrated the association between CBF values and cognitive performance and between CBF and blood pressure. Compared with non-T2DM controls, T2DM patients exhibited decreased CBF, primarily in the visual area and the default mode network (DMN); decreased CBF in these regions was correlated with cognitive performance. There was a significant interaction effect between hypertension and diabetes for CBF in the precuneus and the middle occipital gyrus. Additionally, blood pressure correlated negatively with CBF in T2DM patients. T2DM patients exhibited reduced CBF in the visual area and DMN. Hypertension may facilitate a CBF decrease in the setting of diabetes. T2DM patients may benefit from blood pressure control to maintain their brain perfusion through CBF preservation. |
format | Online Article Text |
id | pubmed-4674216 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Wolters Kluwer Health |
record_format | MEDLINE/PubMed |
spelling | pubmed-46742162016-05-24 Blood Pressure is Associated With Cerebral Blood Flow Alterations in Patients With T2DM as Revealed by Perfusion Functional MRI Xia, Wenqing Rao, Hengyi Spaeth, Andrea M. Huang, Rong Tian, Sai Cai, Rongrong Sun, Jie Wang, Shaohua Medicine (Baltimore) 4300 Type 2 diabetes mellitus (T2DM) and hypertension are both associated with cognitive impairment and brain function abnormalities. We investigated whether abnormal cerebral blood flow (CBF) patterns exists in T2DM patients and possible relationships between aberrant CBF and cognitive performance. Furthermore, we examined the influence of hypertension on CBF alterations in T2DM patients. T2DM patients (n = 38) and non-T2DM subjects (n = 40) were recruited from clinics, hospitals, and normal community health screenings. Cerebral blood flow images were collected and analyzed using arterial spin labeling perfusion functional magnetic resonance imaging (fMRI). Regions with major CBF differences between T2DM patients and non-T2DM controls were detected via 1-way ANOVA. The interaction effects between hypertension and T2DM for CBF alterations were also examined. Correlation analyses illustrated the association between CBF values and cognitive performance and between CBF and blood pressure. Compared with non-T2DM controls, T2DM patients exhibited decreased CBF, primarily in the visual area and the default mode network (DMN); decreased CBF in these regions was correlated with cognitive performance. There was a significant interaction effect between hypertension and diabetes for CBF in the precuneus and the middle occipital gyrus. Additionally, blood pressure correlated negatively with CBF in T2DM patients. T2DM patients exhibited reduced CBF in the visual area and DMN. Hypertension may facilitate a CBF decrease in the setting of diabetes. T2DM patients may benefit from blood pressure control to maintain their brain perfusion through CBF preservation. Wolters Kluwer Health 2015-12-07 /pmc/articles/PMC4674216/ /pubmed/26632913 http://dx.doi.org/10.1097/MD.0000000000002231 Text en Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved. http://creativecommons.org/licenses/by/4.0 This is an open access article distributed under the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0 |
spellingShingle | 4300 Xia, Wenqing Rao, Hengyi Spaeth, Andrea M. Huang, Rong Tian, Sai Cai, Rongrong Sun, Jie Wang, Shaohua Blood Pressure is Associated With Cerebral Blood Flow Alterations in Patients With T2DM as Revealed by Perfusion Functional MRI |
title | Blood Pressure is Associated With Cerebral Blood Flow Alterations in Patients With T2DM as Revealed by Perfusion Functional MRI |
title_full | Blood Pressure is Associated With Cerebral Blood Flow Alterations in Patients With T2DM as Revealed by Perfusion Functional MRI |
title_fullStr | Blood Pressure is Associated With Cerebral Blood Flow Alterations in Patients With T2DM as Revealed by Perfusion Functional MRI |
title_full_unstemmed | Blood Pressure is Associated With Cerebral Blood Flow Alterations in Patients With T2DM as Revealed by Perfusion Functional MRI |
title_short | Blood Pressure is Associated With Cerebral Blood Flow Alterations in Patients With T2DM as Revealed by Perfusion Functional MRI |
title_sort | blood pressure is associated with cerebral blood flow alterations in patients with t2dm as revealed by perfusion functional mri |
topic | 4300 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4674216/ https://www.ncbi.nlm.nih.gov/pubmed/26632913 http://dx.doi.org/10.1097/MD.0000000000002231 |
work_keys_str_mv | AT xiawenqing bloodpressureisassociatedwithcerebralbloodflowalterationsinpatientswitht2dmasrevealedbyperfusionfunctionalmri AT raohengyi bloodpressureisassociatedwithcerebralbloodflowalterationsinpatientswitht2dmasrevealedbyperfusionfunctionalmri AT spaethandream bloodpressureisassociatedwithcerebralbloodflowalterationsinpatientswitht2dmasrevealedbyperfusionfunctionalmri AT huangrong bloodpressureisassociatedwithcerebralbloodflowalterationsinpatientswitht2dmasrevealedbyperfusionfunctionalmri AT tiansai bloodpressureisassociatedwithcerebralbloodflowalterationsinpatientswitht2dmasrevealedbyperfusionfunctionalmri AT cairongrong bloodpressureisassociatedwithcerebralbloodflowalterationsinpatientswitht2dmasrevealedbyperfusionfunctionalmri AT sunjie bloodpressureisassociatedwithcerebralbloodflowalterationsinpatientswitht2dmasrevealedbyperfusionfunctionalmri AT wangshaohua bloodpressureisassociatedwithcerebralbloodflowalterationsinpatientswitht2dmasrevealedbyperfusionfunctionalmri |