Reversible ubiquitination shapes NLRC5 function and modulates NF-κB activation switch

NLRC5 is an important regulator in innate immune responses. However, the ability of NLRC5 to inhibit NF-κB activation is controversial in different cell types. How dynamic modification of NLRC5 shapes NF-κB signaling remains unknown. We demonstrated that NLRC5 undergoes robust ubiquitination by TRAF...

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Detalles Bibliográficos
Autores principales: Meng, Qingcai, Cai, Chunmei, Sun, Tingzhe, Wang, Qianliang, Xie, Weihong, Wang, Rongfu, Cui, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2015
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4674279/
https://www.ncbi.nlm.nih.gov/pubmed/26620909
http://dx.doi.org/10.1083/jcb.201505091

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