Targeting megakaryocytic induced fibrosis by AURKA inhibition in the myeloproliferative neoplasms

Primary myelofibrosis (PMF) is characterized by bone marrow fibrosis, myeloproliferation, extramedullary hematopoiesis, splenomegaly and leukemic progression. Moreover, the bone marrow and spleen of patients are full of atypical megakaryocytes that are postulated to contribute to fibrosis through th...

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Detalles Bibliográficos
Autores principales: Wen, Qiang Jeremy, Yang, Qiong, Goldenson, Benjamin, Malinge, Sébastien, Lasho, Terra, Schneider, Rebekka K., Breyfogle, Lawrence J., Schultz, Rachael, Gilles, Laure, Koppikar, Priya, Abdel-Wahab, Omar, Pardanani, Animesh, Stein, Brady, Gurbuxani, Sandeep, Mullally, Ann, Levine, Ross, Tefferi, Ayalew, Crispino, John D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4674320/
https://www.ncbi.nlm.nih.gov/pubmed/26569382
http://dx.doi.org/10.1038/nm.3995

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