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Comparison of Adipose Distribution Indices with Gold Standard Body Composition Assessments in the EMPA-REG H2H SU Trial: A Body Composition Sub-Study

INTRODUCTION: Excess adiposity contributes to cardiometabolic disease. Although adipose depots can be measured using imaging, implementation remains limited in practice. Data comparing surrogate indices of total and visceral adiposity with gold standard measurements in the context of a clinical tria...

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Autores principales: Neeland, Ian J., McGuire, Darren K., Eliasson, Björn, Ridderstråle, Martin, Zeller, Cordula, Woerle, Hans J., Broedl, Uli C., Johansen, Odd Erik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Healthcare 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4674478/
https://www.ncbi.nlm.nih.gov/pubmed/26608511
http://dx.doi.org/10.1007/s13300-015-0146-7
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author Neeland, Ian J.
McGuire, Darren K.
Eliasson, Björn
Ridderstråle, Martin
Zeller, Cordula
Woerle, Hans J.
Broedl, Uli C.
Johansen, Odd Erik
author_facet Neeland, Ian J.
McGuire, Darren K.
Eliasson, Björn
Ridderstråle, Martin
Zeller, Cordula
Woerle, Hans J.
Broedl, Uli C.
Johansen, Odd Erik
author_sort Neeland, Ian J.
collection PubMed
description INTRODUCTION: Excess adiposity contributes to cardiometabolic disease. Although adipose depots can be measured using imaging, implementation remains limited in practice. Data comparing surrogate indices of total and visceral adiposity with gold standard measurements in the context of a clinical trial population are lacking. We explored the relationships between adipose distribution indices and imaging assessments of body composition using baseline data from the EMPA-REG H2H SU™ trial. METHODS: 118 participants from the Phase III trial of empagliflozin 25 mg vs. glimepiride 1–4 mg enrolled in a dedicated sub-study underwent assessment of total fat and fat-free mass by dual x-ray absorptiometry (n = 93) and abdominal visceral (VAT) and subcutaneous adipose tissue by magnetic resonance imaging (n = 99). Correlations with waist circumference (WC), estimated total body fat (eTBF), index of central obesity (ICO), and visceral adiposity index (VAI) were assessed. RESULTS: eTBF was highly representative of total body fat (Spearman’s ρ = 0.73, P < 0.001) but not associated with VAT. WC and ICO were strongly, and VAI to a lesser degree, correlated with VAT (ρ = 0.66, P < 0.001; ρ = 0.52, P < 0.001; ρ = 0.24, P = 0.02, respectively). CONCLUSION: These findings support the use of eTBF and WC or ICO as surrogate indices for total body fat and VAT, respectively, in the absence of gold standard imaging methodology. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s13300-015-0146-7) contains supplementary material, which is available to authorized users.
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spelling pubmed-46744782015-12-17 Comparison of Adipose Distribution Indices with Gold Standard Body Composition Assessments in the EMPA-REG H2H SU Trial: A Body Composition Sub-Study Neeland, Ian J. McGuire, Darren K. Eliasson, Björn Ridderstråle, Martin Zeller, Cordula Woerle, Hans J. Broedl, Uli C. Johansen, Odd Erik Diabetes Ther Brief Report INTRODUCTION: Excess adiposity contributes to cardiometabolic disease. Although adipose depots can be measured using imaging, implementation remains limited in practice. Data comparing surrogate indices of total and visceral adiposity with gold standard measurements in the context of a clinical trial population are lacking. We explored the relationships between adipose distribution indices and imaging assessments of body composition using baseline data from the EMPA-REG H2H SU™ trial. METHODS: 118 participants from the Phase III trial of empagliflozin 25 mg vs. glimepiride 1–4 mg enrolled in a dedicated sub-study underwent assessment of total fat and fat-free mass by dual x-ray absorptiometry (n = 93) and abdominal visceral (VAT) and subcutaneous adipose tissue by magnetic resonance imaging (n = 99). Correlations with waist circumference (WC), estimated total body fat (eTBF), index of central obesity (ICO), and visceral adiposity index (VAI) were assessed. RESULTS: eTBF was highly representative of total body fat (Spearman’s ρ = 0.73, P < 0.001) but not associated with VAT. WC and ICO were strongly, and VAI to a lesser degree, correlated with VAT (ρ = 0.66, P < 0.001; ρ = 0.52, P < 0.001; ρ = 0.24, P = 0.02, respectively). CONCLUSION: These findings support the use of eTBF and WC or ICO as surrogate indices for total body fat and VAT, respectively, in the absence of gold standard imaging methodology. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s13300-015-0146-7) contains supplementary material, which is available to authorized users. Springer Healthcare 2015-11-25 2015-12 /pmc/articles/PMC4674478/ /pubmed/26608511 http://dx.doi.org/10.1007/s13300-015-0146-7 Text en © The Author(s) 2015 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits any noncommercial use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Brief Report
Neeland, Ian J.
McGuire, Darren K.
Eliasson, Björn
Ridderstråle, Martin
Zeller, Cordula
Woerle, Hans J.
Broedl, Uli C.
Johansen, Odd Erik
Comparison of Adipose Distribution Indices with Gold Standard Body Composition Assessments in the EMPA-REG H2H SU Trial: A Body Composition Sub-Study
title Comparison of Adipose Distribution Indices with Gold Standard Body Composition Assessments in the EMPA-REG H2H SU Trial: A Body Composition Sub-Study
title_full Comparison of Adipose Distribution Indices with Gold Standard Body Composition Assessments in the EMPA-REG H2H SU Trial: A Body Composition Sub-Study
title_fullStr Comparison of Adipose Distribution Indices with Gold Standard Body Composition Assessments in the EMPA-REG H2H SU Trial: A Body Composition Sub-Study
title_full_unstemmed Comparison of Adipose Distribution Indices with Gold Standard Body Composition Assessments in the EMPA-REG H2H SU Trial: A Body Composition Sub-Study
title_short Comparison of Adipose Distribution Indices with Gold Standard Body Composition Assessments in the EMPA-REG H2H SU Trial: A Body Composition Sub-Study
title_sort comparison of adipose distribution indices with gold standard body composition assessments in the empa-reg h2h su trial: a body composition sub-study
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4674478/
https://www.ncbi.nlm.nih.gov/pubmed/26608511
http://dx.doi.org/10.1007/s13300-015-0146-7
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