The Oncogenic Roles of DICER1 RNase IIIb Domain Mutations in Ovarian Sertoli-Leydig Cell Tumors()()

DICER1, an endoribonuclease required for microRNA (miRNA) biogenesis, is essential for embryogenesis and the development of many organs including ovaries. We have recently identified somatic hotspot mutations in RNase IIIb domain of DICER1 in half of ovarian Sertoli-Leydig cell tumors, a rare class...

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Detalles Bibliográficos
Autores principales: Wang, Yemin, Chen, Jiamin, Yang, Winnie, Mo, Fan, Senz, Janine, Yap, Damian, Anglesio, Michael S., Gilks, Blake, Morin, Gregg B., Huntsman, David G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4674484/
https://www.ncbi.nlm.nih.gov/pubmed/26408257
http://dx.doi.org/10.1016/j.neo.2015.08.003

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