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The Contrived Mutant p53 Oncogene – Beyond Loss of Functions
Mutations in p53 are almost synonymous with cancer – be it susceptibility to the disease or response to treatment – and therefore, are a critical determinant of overall survival. As most of these mutations occur in the DNA-binding domain of p53, many of the clinical correlations with mutant p53 have...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Frontiers Media S.A.
2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4674554/ https://www.ncbi.nlm.nih.gov/pubmed/26697411 http://dx.doi.org/10.3389/fonc.2015.00276 |